Odorant receptor polymorphisms and natural variation in olfactory behavior in Drosophila melanogaster.

Genetics
Stephanie M RollmannRobert R H Anholt

Abstract

Animals perceive and discriminate among a vast array of sensory cues in their environment. Both genetic and environmental factors contribute to individual variation in behavioral responses to these cues. Here, we asked to what extent sequence variants in six Drosophila melanogaster odorant receptor (Or) genes are associated with variation in behavioral responses to benzaldehyde by sequencing alleles from a natural population. Sequence analyses showed signatures of deviations from neutrality for Or42b and Or85f, and linkage disequilibrium analyses showed a history of extensive recombination between polymorphic markers for all six Or genes. We identified polymorphisms in Or10a, Or43a, and Or67b that were significantly associated with variation in response to benzaldehyde. To verify these associations, we repeated the analyses with an independent set of behavioral measurements of responses to a structurally similar odorant, acetophenone. Association profiles for both odorants were similar with many polymorphisms and haplotypes associated with variation in responsiveness to both odorants. Some polymorphisms, however, were associated with one, but not the other odorant. We also observed a correspondence between behavioral response t...Continue Reading

References

Jun 20, 1991·Nature·J H McDonald, M Kreitman
Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Aug 1, 1993·Genetics·B CharlesworthD Charlesworth
Jan 1, 1996·Molecular Biology and Evolution·E N Moriyama, J R Powell
Nov 15, 1996·Cell·P MombaertsR Axel
Mar 31, 1999·The Journal of Comparative Neurology·P P LaissueR F Stocker
Aug 16, 2000·Cell·L B VosshallR Axel
Jun 8, 2001·Neuron·M de BruyneJ R Carlson
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·C H WetzelH Hatt
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·K F Störtkuhl, R Kettler
Jan 22, 2002·Nature Neuroscience·Xinmin Zhang, Stuart Firestein
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hugh M RobertsonJohn R Carlson
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D R ReedA A Bachmanov
Apr 15, 2004·Genomics·Xinmin ZhangStuart Firestein
Jun 24, 2004·Cell·Elissa A HallemJohn R Carlson
Sep 9, 2004·Bioinformatics·Eric W Price, Ignazio Carbone
Nov 3, 2004·Nature Reviews. Genetics·Robert R H Anholt, Trudy F C Mackay
Dec 21, 2004·Nucleic Acids Research·Rachel A DrysdaleUNKNOWN FlyBase Consortium
Feb 23, 2005·Current Biology : CB·Walton D JonesLeslie B Vosshall
Sep 6, 2005·Current Biology : CB·Elane Fishilevich, Leslie B Vosshall
Apr 18, 2006·Cell·Elissa A Hallem, John R Carlson
Jul 11, 2006·Science·Hopi E HoekstraJanet P Crossland
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel B CampbellPat Levitt
Nov 23, 2006·The Journal of Biological Chemistry·Tatjana AbaffyCharles W Luetje
May 18, 2007·Annual Review of Neuroscience·Leslie B Vosshall, Reinhard F Stocker
Sep 18, 2007·Nature·Andreas KellerHiroaki Matsunami

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Citations

Jan 13, 2012·The ISME Journal·Qun MaThomas K Wood
Aug 21, 2013·Nature Reviews. Genetics·Sidi ChenManyuan Long
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Allison F Carey, John R Carlson
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shilpa SwarupRobert R H Anholt
Dec 24, 2015·Frontiers in Behavioral Neuroscience·Elisabetta Versace, Giorgio Vallortigara
May 21, 2013·Genes, Brain, and Behavior·E B BrownS M Rollmann
Feb 18, 2015·Chemical Senses·Gunjan H AryaRobert R H Anholt
Nov 5, 2013·Behavioural Brain Research·Mohammad HaddadiS R Ramesh
Jun 13, 2009·BMC Biology·Alexis C EdwardsTrudy F C Mackay
Sep 21, 2013·Annual Review of Genetics·Manyuan LongMaria D Vibranovski
Sep 2, 2016·Proceedings. Biological Sciences·Amber Crowley-GallStephanie M Rollmann
Nov 15, 2017·BMC Genomics·Elizabeth B BrownStephanie M Rollmann
Feb 18, 2016·PLoS Neglected Tropical Diseases·Rosaline MachariaDaniel Masiga
Oct 10, 2018·The Journal of Heredity·Amber Crowley-GallStephanie M Rollmann
Nov 9, 2016·Biology Direct·Craig E Stanley, Rob J Kulathinal
Mar 20, 2020·Archives of Insect Biochemistry and Physiology·Giulia CordaGiorgia Sollai
Aug 16, 2018·Current Zoology·Laurel R YoheUNKNOWN Handling editor: Rebecca Fuller
Feb 16, 2021·Molecular Biology and Evolution·Sylvia M DurkinLi Zhao

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