Odors enhance slow-wave activity in non-rapid eye movement sleep

Journal of Neurophysiology
Ofer PerlIlana S Hairston

Abstract

Most forms of suprathreshold sensory stimulation perturb sleep. In contrast, presentation of pure olfactory or mild trigeminal odorants does not lead to behavioral or physiological arousal. In fact, some odors promote objective and subjective measures of sleep quality in humans and rodents. The brain mechanisms underlying these sleep-protective properties of olfaction remain unclear. Slow oscillations in the electroencephalogram (EEG) are a marker of deep sleep, and K complexes (KCs) are an EEG marker of cortical response to sensory interference. We therefore hypothesized that odorants presented during sleep will increase power in slow EEG oscillations. Moreover, given that odorants do not drive sleep interruption, we hypothesized that unlike other sensory stimuli odorants would not drive KCs. To test these hypotheses we used polysomnography to measure sleep in 34 healthy subjects (19 women, 15 men; mean age 26.5 ± 2.5 yr) who were repeatedly presented with odor stimuli via a computer-controlled air-dilution olfactometer over the course of a single night. Each participant was exposed to one of four odorants, lavender oil (n = 13), vetiver oil (n = 5), vanillin (n = 12), or ammonium sulfide (n = 4), for durations of 5, 10, and 2...Continue Reading

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Citations

Jun 20, 2019·Journal of Neurophysiology·Detlef H HeckLeslie M Kay
Sep 27, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Brenda McDonnell, Patricia Newcomb
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Dec 16, 2021·The FEBS Journal·José Manuel DuhartKyunghee Koh

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