ODVBA: optimally-discriminative voxel-based analysis

IEEE Transactions on Medical Imaging
Tianhao Zhang, Christos Davatzikos

Abstract

Gaussian smoothing of images prior to applying voxel-based statistics is an important step in voxel-based analysis and statistical parametric mapping (VBA-SPM) and is used to account for registration errors, to Gaussianize the data and to integrate imaging signals from a region around each voxel. However, it has also become a limitation of VBA-SPM based methods, since it is often chosen empirically and lacks spatial adaptivity to the shape and spatial extent of the region of interest, such as a region of atrophy or functional activity. In this paper, we propose a new framework, named optimally-discriminative voxel-based analysis (ODVBA), for determining the optimal spatially adaptive smoothing of images, followed by applying voxel-based group analysis. In ODVBA, nonnegative discriminative projection is applied regionally to get the direction that best discriminates between two groups, e.g., patients and controls; this direction is equivalent to local filtering by an optimal kernel whose coefficients define the optimally discriminative direction. By considering all the neighborhoods that contain a given voxel, we then compose this information to produce the statistic for each voxel. Finally, permutation tests are used to obtain ...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Aug 1, 1991·Annals of Neurology·A C McKeeN W Kowall
Sep 1, 1986·Investigative Radiology·C E Metz
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A P HolmesI Ford
Oct 1, 1998·Journal of Computer Assisted Tomography·A F GoldszalS M Resnick
Nov 26, 1999·IEEE Transactions on Medical Imaging·D L Pham, J L Prince
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·G B FrisoniM P Laakso
Feb 11, 2003·IEEE Transactions on Medical Imaging·Dinggang Shen, Christos Davatzikos
Jul 10, 2003·Lancet Neurology·John AshburnerPaul M Thompson
Sep 11, 2003·Journal of Cognitive Neuroscience·Thomas A CarlsonSheng He
Mar 19, 2004·IEEE Transactions on Medical Imaging·Alle Meije Wink, Jos B T M Roerdink
Jun 12, 2004·IEEE Transactions on Medical Imaging·Edward H HerskovitsChristos Davatzikos
Oct 19, 2005·IEEE Transactions on Medical Imaging·Rong Chen, Edward H Herskovits
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nikolaus KriegeskortePeter Bandettini
Jul 21, 2006·Brain : a Journal of Neurology·Henry EnglerAgneta Nordberg
Aug 11, 2006·Trends in Cognitive Sciences·Kenneth A NormanJames V Haxby
Jan 25, 2007·IEEE Transactions on Medical Imaging·Yong FanChristos Davatzikos
Jun 19, 2007·Neural Computation·Fei ShaDaniel D Lee
Aug 11, 2007·NeuroImage·Dimitri Van De VilleMichael Unser
Sep 7, 2007·NeuroImage·Nikolaus Kriegeskorte, Peter Bandettini
Jan 16, 2008·IEEE Transactions on Pattern Analysis and Machine Intelligence·Li Yang
Jan 19, 2008·Brain : a Journal of Neurology·Stefan KlöppelRichard S J Frackowiak
Oct 27, 2009·NeuroImage·Matthew ToewsTal Arbel

❮ Previous
Next ❯

Citations

Nov 4, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 16, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 15, 2015·NeuroImage·Melanie GanzUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 26, 2016·NeuroImage·Mohammad R ArbabshiraniVince D Calhoun
Sep 18, 2013·IEEE Transactions on Medical Imaging·Jane RondinaJanaina Mourao-Miranda
Feb 26, 2016·Brain : a Journal of Neurology·Mohamad HabesChristos Davatzikos
Apr 6, 2013·NeuroImage·Joset A EtzelTodd S Braver
Aug 13, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.