Apr 5, 2020

Topological Analysis of Differential Effects of Ketamine and Propofol Anesthesia on Brain Dynamics

BioRxiv : the Preprint Server for Biology
Thomas F VarleyA. Patania


Research into the neural correlates of consciousness has found that the vividness and complexity of conscious experience is related to the structure of brain dynamics, and that alterations to consciousness track changes in temporal evolution of brain states. Despite inducing externally similar states, propofol and ketamine produce different subjective states of consciousness. Here we explore the different effects of these two anaesthetics on the structure of dynamical attractors reconstructed from brain activity recorded electrophysiologically from cerebral cortex of a non-human primate. We used two different methods of attractor reconstruction. The first embeds the recordings in a continuous high-dimensional manifold on which we use topological data analysis to infer the presence (or absence) of higher-order dynamics. The second reconstruction, an ordinal partition network embedding, allows us to create a discrete state-transition network approximation of a continuous attractor, which is amenable to information-theoretic analysis and contains rich information about state-transition dynamics. We find significant differences between the awake, ketamine, and propofol conditions. Propofol significantly decreased the expression of ...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Computer Software
Sequence Determinations
Gene Expression
RNA, Small Cytoplasmic
Statistical Technique
Infective Otitis Externa

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

BioRxiv : the Preprint Server for Biology
Thomas F VarleyJ. Beggs
Korean journal of anesthesiology
Anju Romina Bhalotra
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Robert S. SeiglerDebra K. Wilfong
© 2020 Meta ULC. All rights reserved