Oesophageal adenocarcinoma has a higher risk of lymph node metastasis than squamous cell carcinoma: a propensity score-matched study

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Han-Yu DengYi-Dan Lin

Abstract

The pattern of lymph node metastasis is a predominant element in tumour biology, which is closely related to optimal therapeutic modality. Controversy remains as to which histopathology type of oesophageal cancer-adenocarcinoma or squamous cell carcinoma (SCC)-is more likely to have lymph node metastasis. Therefore, this study aimed to apply propensity score-matched analysis to draw an objective conclusion for providing initial evidence of the potential need for different therapeutic strategies for these 2 cancer types. A retrospective analysis of patients who underwent radical oesophagectomy with lymphadenectomy, but without preoperative treatment for pathologically and immunohistochemically diagnosed oesophageal adenocarcinoma or SCC, was conducted. Data for analysis included age, gender, body mass index, pathologic findings, procedures of oesophagectomy and rate of lymph node metastasis. Propensity score-matched analysis was conducted to eliminate the bias effects of confounding factors. A total of 1204 patients (including 118 with adenocarcinoma and 1086 with SCC) from January 2012 to June 2016 was included for analysis. In the analysis of unmatched patients, those with adenocarcinomas had significantly larger mean numbers ...Continue Reading

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Citations

Nov 1, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H-Y DengK-L Huang
Oct 1, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Sabrina M SaeedJose M Pimiento
May 10, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Panpan Zha, Han-Yu Deng
May 10, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Shinji Mine, Masayuki Watanabe
Jun 22, 2020·The Journal of Surgical Research·Jingpu WangDongfei Yin

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