Oesophageal and proximal gastric adenocarcinomas are rare after detection of Helicobacter pylori infection.

Alimentary Pharmacology & Therapeutics
Shria KumarDavid S Goldberg

Abstract

Helicobacter pylori infection is the most important risk factor for non-proximal gastric adenocarcinoma, yet some posit it is protective against oesophageal adenocarcinoma and proximal gastric cancers. To evaluate the incidence of and risk factors for future oesophageal and proximal gastric cancers, utilizing the largest North American cohort of patients with previously identified H pylori. Also to identify whether treatment and eradication of H pylori alter future oesophageal and proximal gastric cancer risk. Retrospective cohort study within the Veterans Administration of 36 803 patients (median age 60.4 years; 91.8% male) with confirmed H pylori between 01 January 1994 and 31 December 2018. Primary outcome was diagnosis of future oesophageal and proximal gastric cancers. A time to event with competing risk analysis was performed, evaluating patient factors and whether the patient received H pylori treatment. Secondary analysis of those treated evaluated whether confirmed eradication was associated with cancer. The cumulative incidence of oesophageal and proximal gastric cancers 5, 10 and 15 years after H pylori detection was 0.145%, 0.26% and 0.34%. Risk of future oesophageal or proximal gastric cancer was similar amongst wh...Continue Reading

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Citations

May 20, 2020·Alimentary Pharmacology & Therapeutics·Apostolis PapaefthymiouJannis Kountouras
Sep 13, 2020·Helicobacter·Marino VeneritoPeter Malfertheiner
May 24, 2020·Alimentary Pharmacology & Therapeutics·Yulan Sun
Aug 28, 2020·Alimentary Pharmacology & Therapeutics·Alphons J M VermorkenYali Cui
Mar 12, 2021·GastroHep·Shria KumarDavid S Goldberg
Apr 16, 2021·Digestive Diseases and Sciences·Shria KumarDavid E Kaplan
May 13, 2021·Best Practice & Research. Clinical Gastroenterology·Jan BornscheinMarnix Jansen
Sep 11, 2021·Cellular and Molecular Gastroenterology and Hepatology·Annemieke SmetJan Bornschein

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