Oesophageal GIST-A rare breed case report and review of the literature

International Journal of Surgery Case Reports
Kristof NemethAshraf Rasheed

Abstract

Gastrointestinal stromal tumours (GIST) account for only one percent of all gastrointestinal malignancies. A 53 year old lady presented to the gastroenterology clinic with iron deficiency anaemia. Oesophagogastroduodenoscopy (OGD) and computed tomography (CT) demonstrated a non-obstructing 7cm submucosal oesophageal lesion. An oesophagectomy was performed and subsequent histology sections showed a well-circumscribed spindle cell tumour without any cellular atypia. Immunohistochemistry on the tumour was negative for S100 and positive for smooth muscle actin and desmin. C-kit (CD117) showed focal positivity in some of the tumour cells and the overall features were of a gastro-intestinal stromal tumour (GIST). The patient has been fully compliant with the follow-up arrangements and is disease-free six years after her original operation. GISTs are mesenchymal tumours of the gastrointestinal (GI) tract that express the KIT protein. The incidence rate for GIST is 15 cases to one million in the USA. GISTs in the oesophagus are rare (5%) and their management is surrounded by some debate. Once the diagnosis has been secured the patient should be evaluated for suitability for surgical resection. Optimal surgical therapy should aim to ach...Continue Reading

References

Mar 18, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Angela D LevyMarkku Miettinen
Feb 25, 2005·AJR. American Journal of Roentgenology·Kumaresan SandrasegaranJohn D Henley
Oct 28, 2005·Advances in Surgery·David T Efron, Keith D Lillemoe
Jan 2, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G F SamelisG C Zografos
Feb 27, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I AhmedS L Parsons
Mar 14, 2008·Langenbeck's Archives of Surgery·Konrad Klaus RichterAnnelore Altendorf-Hofmann
Aug 4, 2009·World Journal of Surgical Oncology·Michael StamatakosMichael Safioleas
Jun 14, 2013·Annals of Surgical Oncology·Piotr RutkowskiFrits van Coevorden

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Citations

Sep 9, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K PenceM P Kim
Nov 2, 2020·BMJ Case Reports·Filipa CostaPaulo Ramos
Aug 28, 2021·Diagnostics·Irene Alexandra SpiridonIrina Draga Căruntu

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Methods Mentioned

BETA
surgical resection
imaging techniques
biopsy
biopsies
dissemination

Software Mentioned

MRo

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