Oesophageal motility and bolus transit abnormalities increase in parallel with the severity of gastro-oesophageal reflux disease

Alimentary Pharmacology & Therapeutics
E SavarinoV Savarino

Abstract

Limited data are available regarding the frequency of oesophageal motility and bolus transit abnormalities in subgroups of patients with gastro-oesophageal reflux disease (GERD). To assess oesophageal motility and bolus transit in endoscopically defined GERD subgroups. Patients (N=755) with typical reflux symptoms underwent upper endoscopy, conventional or impedance oesophageal manometry and/or impedance-pH testing. They were divided into: erosive oesophagitis (EO; N=340), Barrett Oesophagus (BO; N=106), non-erosive reflux disease (NERD; endoscopy-, abnormal pH and/or SAP/SI+; N=239) and functional heartburn (FH; endoscopy-, normal pH and SAP/SI-; N=70). Manometric patterns and bolus transit were defined according to previously published criteria. Increasing GERD severity was associated with decreased lower oesophageal sphincter resting pressure (P< 0.05) and distal oesophageal amplitude (P<0.01), higher prevalence of hiatal hernia (P<0.01) and increased prevalence of ineffective oesophageal motility (P<0.01). Patients with EO and BO had a significantly lower percentage of complete bolus transit compared with NERD and FH (P<0.01). Overall, abnormal bolus transit (ABT) for liquid swallows was found in 12% of FH, 20% of NERD, 54%...Continue Reading

References

Jan 1, 1988·Gastroenterology·P J KahrilasW J Hogan
Oct 1, 1986·Gastroenterology·P J KahrilasA Reece
Dec 1, 1995·Gastroenterology·P J KahrilasP Pouderoux
May 22, 2001·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·U DienerL W Way
Jun 20, 2001·Gut·S J Spechler, D O Castell
Dec 26, 2001·The American Journal of Medicine·R C Orlando
Mar 21, 2002·Journal of Gastroenterology and Hepatology·R Ouatu-LascarG Triadafilopoulos
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Radu Tutuian, Donald O Castell
Feb 18, 2005·European Journal of Gastroenterology & Hepatology·Gerson R DominguesHuan N Nguyen
Feb 19, 2005·Journal of Clinical Gastroenterology·Eponina Maria de Oliveira LemmeAngela Alvariz
Feb 17, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P ZentilinV Savarino
Apr 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M FrazzoniV Savarino
May 9, 2006·Gastroenterology·Jean Paul GalmicheAndre J P M Smout
Aug 25, 2006·The American Journal of Gastroenterology·Nimish VakilUNKNOWN Global Consensus Group
May 8, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Justin C Y WuJoseph J Y Sung
Sep 11, 2007·Digestive Diseases·Vincenzo SavarinoPietro Dulbecco
Nov 23, 2007·Journal of Gastroenterology and Hepatology·Katsuhiko IwakiriRichard H Holloway
Jan 8, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E Savarino, R Tutuian
Feb 23, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C L ChenI J Cook
Sep 9, 2008·The American Journal of Gastroenterology·Edoardo SavarinoVincenzo Savarino
Oct 17, 2008·The New England Journal of Medicine·Peter J Kahrilas
Jun 11, 2010·Journal of Neurogastroenterology and Motility·Tiberiu Hershcovici, Ronnie Fass
Jun 19, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E SavarinoV Savarino
Mar 8, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo SavarinoVincenzo Savarino

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Citations

Mar 27, 2013·Nature Reviews. Gastroenterology & Hepatology·Edoardo SavarinoVincenzo Savarino
Feb 6, 2013·Rheumatology·Edoardo SavarinoAntonio Gasbarrini
Nov 19, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Edoardo SavarinoVincenzo Savarino
May 3, 2014·Surgical Endoscopy·Karl Hermann FuchsUNKNOWN European Association of Endoscopic Surgery (EAES)
Sep 3, 2014·La Presse médicale·Edoardo SavarinoVincenzo Savarino
Sep 14, 2014·Gastrointestinal Endoscopy Clinics of North America·Marcelo F Vela
Aug 6, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Aleksandar P SimićPredrag M Peško
Apr 9, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marzio FrazzoniGianluigi Melotti
Nov 1, 2011·Journal of Gastroenterology·Edoardo SavarinoVincenzo Savarino
Sep 26, 2013·Wiener klinische Wochenschrift·Johannes LenglingerSebastian F Schoppmann
Dec 22, 2015·Current Gastroenterology Reports·Ala' A Abdel Jalil, Donald O Castell
Nov 18, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M D MelloC P Gyawali
Dec 15, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I MartinucciN de Bortoli
Jan 29, 2013·Seminars in Arthritis and Rheumatism·Lorenzo GemignaniEdoardo Savarino
Sep 15, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Valentina ManciniOsvaldo Borrelli
Sep 13, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nicola de BortoliSantino Marchi
Jun 12, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·O BorrelliG L De'angelis
Oct 13, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M FrazzoniG Melotti
Oct 15, 2013·Annals of the New York Academy of Sciences·Andrew M BellizziXiaoxin Chen
Oct 15, 2013·Annals of the New York Academy of Sciences·Kenneth DeVaultJohn V Reynolds
Aug 29, 2013·Journal of Gastroenterology and Hepatology·Chien-Lin ChenTso-Tsai Liu
Nov 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R SweisM Fox
Aug 2, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R A CassianiR O Dantas
Apr 22, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·O M CrespinC A Pellegrini
May 27, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S ToloneE Savarino
May 2, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F B van HoeijA J Bredenoord
Nov 19, 2014·Nature Reviews. Gastroenterology & Hepatology·Frank Zerbib, Taher Omari
Mar 7, 2015·Best Practice & Research. Clinical Gastroenterology·Sabine Roman, Peter J Kahrilas
Sep 10, 2016·Canadian Journal of Gastroenterology & Hepatology·Thirumazhisai GunasekaranJames Berman
Jul 23, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo SavarinoRoberto Penagini
Oct 28, 2016·Annals of the New York Academy of Sciences·Edoardo SavarinoEllen Stein
Nov 7, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M RibolsiM Cicala
Aug 26, 2016·Journal of Neurogastroenterology and Motility·Christian LottrupAsbjørn M Drewes
Sep 8, 2016·Journal of Neurogastroenterology and Motility·Liuqin JiangLin Lin
Apr 4, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S RomanUNKNOWN GERD consensus group
Mar 28, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael F VaeziNicholas J Shaheen
May 26, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C P GyawaliUNKNOWN International GERD Consensus Working Group
Jan 8, 2015·Journal of Pediatric Gastroenterology and Nutrition·Renato TambucciOsvaldo Borrelli
Mar 16, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S SanagapalliR Sweis
Apr 3, 2018·Journal of Neurogastroenterology and Motility·Camille BazinVeronique Vitton
Mar 1, 2018·Journal of Neurogastroenterology and Motility·Michel R FernandesFernando Fornari
Dec 22, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A RengarajanC P Gyawali
Sep 28, 2017·Nature Reviews. Gastroenterology & Hepatology·Edoardo SavarinoUNKNOWN International Working Group for Disorders of Gastrointestinal Motility and Function
Dec 10, 2016·World Journal of Gastrointestinal Surgery·Salvatore ToloneLudovico Docimo
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Nicola de BortoliEdoardo Vincenzo Savarino
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Irene MartinucciSantino Marchi

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