Oesophageal pemphigoid: a rare cause of dysphagia

Clinical Journal of Gastroenterology
Michael McFarlaneBen Disney

Abstract

Pemphigus vulgaris (PV) is a rare autoimmune bullous disease which affects the skin and mucous membranes. Oesophageal involvement is rare and has previously been limited to case reports and case series. A recent large case series of 477 PV patients showed that 26/477 (5.4%) had symptomatic oesophageal involvement. We present the case of a 54-year-old Somalian lady with a 10-year history of cutaneous PV, currently in remission, who developed dysphagia and odynophagia and was subsequently found to have oesophageal PV involvement with multiple flaccid bullae which were positive for anti-DSG3 antibodies on in-direct immunofluorescence. She had her treatment switched from azathioprine to mycophenolate and prednisolone, leading to resolution of her symptoms.

References

Jun 1, 1981·Journal of the American Academy of Dermatology·R P KaplanV D Newcomer
Feb 18, 1999·The Journal of Clinical Investigation·M G MahoneyJ R Stanley
Jun 18, 2011·Clinics in Dermatology·Pascal Joly, Noémie Litrowski
Nov 7, 2015·Clinical, Cosmetic and Investigational Dermatology·Stamatis GregoriouDimitris Rigopoulos
Apr 19, 2017·The British Journal of Dermatology·O ZehouC Prost-Squarcioni
Feb 27, 2018·Immunologic Research·Khalaf Kridin

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Citations

Jan 1, 2021·Histopathology·Victoria Malone, Kieran Sheahan
Jun 8, 2021·Seminars in Immunopathology·Luc BiedermannPhilipp Schreiner
Nov 26, 2019·Case Reports in Gastroenterology·Sara GhoneimAmy Calderon

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