Oesophageal signet ring cell carcinoma as complication of gastro-oesophageal reflux disease

Alimentary Pharmacology & Therapeutics
K O TurnerA Sonnenberg

Abstract

Signet ring cell carcinoma occurs as a histological variant of oesophageal adenocarcinoma. In a cross-sectional study, to pursue the hypothesis that oesophageal signet ring cell cancers constitute a complication of gastro-oesophageal reflux disease. In a large national database of histopathology records, we accumulated 91 802 patients with Barrett's oesophagus (BE), 2817 with oesophageal nonsignet ring adenocarcinoma (EAC) and 278 with oesophageal signet ring cell carcinoma (SRC). The three groups were compared with respect to their clinical and demographic characteristics, as well as socio-economic risk factors (associated with patients' place of residence). About 9% of all oesophageal adenocarcinomas harboured features of signet ring cell carcinoma. Patients with oesophageal adenocarcinoma and signet ring cell carcinoma were characterised by almost identical epidemiological patterns. Patients with either cancer type were slightly older than those with Barrett's oesophagus (EAC 68.0, SRC 66.7 vs. BE 63.7 years), and both showed a striking male predominance (EAC and SRC 85% vs. BE 67%). Both cancer types were associated with a similar set of alarm symptoms, such as dysphagia, pain and weight loss. The distribution by race (Whit...Continue Reading

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Citations

Dec 8, 2017·Journal of Clinical Pathology·Christopher William BleaneyYeng Ang
Oct 27, 2021·Alimentary Pharmacology & Therapeutics·Robert M Genta, Amnon Sonnenberg

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