Oesophago-gastric junction opening function: assessment using ultrasound imaging and the effects of atropine

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Jianmin LiuR K Mittal

Abstract

Relaxation and opening of the oesophago-gastric junction (OGJ) is crucial for oesophageal transport. A novel ultrasound technique was used to determine OGJ opening, before and after atropine, in 12 normals. An ultrasound probe, a solid-state pressure transducer and an infusion tube were placed inside a 20-mm diameter bag, which was placed across the OGJ. At various bag pressures ultrasound transducer was pulled across the bag. Acquired B-mode ultrasound images were converted into M-mode image to display the oesophagus, OGJ and stomach. At low bag-pressure (< 20 mmHg), the OGJ but not oesophagus and stomach, is collapsed around the bag. Increasing bag pressure results in gradual opening of the OGJ from distal end. M-mode image identified the narrowest region of OGJ and corresponding cross-sectional area (CSA) was measured. Mean bag pressure to initial OGJ opening was 18 mmHg. Linear relationship between bag-pressure and OGJ-CSA was observed. Atropine reduced opening bag pressure and shifted the OGJ pressure-CSA curve upward without altering slope, i.e. compliance. Our novel ultrasound technique to study the OGJ opening function shows two distinct components; firstly, related to the tonic OGJ contraction and secondly, to passive ...Continue Reading

References

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Citations

May 20, 2015·Journal of Gastroenterology·Christian LottrupBarry P McMahon
Nov 8, 2016·Chest·Syed Rizwan Ali, Atul C Mehta
Apr 3, 2018·Journal of Neurogastroenterology and Motility·Hans Gregersen, Kar Man Lo
Sep 30, 2017·Journal of Veterinary Internal Medicine·M I KoukiT S Rallis
Jun 5, 2007·Current Opinion in Gastroenterology·Hanneke Beaumont, Guy Boeckxstaens
Feb 25, 2014·Acta Biologica Hungarica·M Thiruvengadam, I M Chung
Aug 20, 2020·Annals of the New York Academy of Sciences·John O ClarkeMarcelo F Vela
Jan 22, 2022·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Anand S JainRavinder Mittal

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