Oestrogen activity of the serum in adolescents with Type 1 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
Daniela MartínezEthel Codner

Abstract

To assess serum oestrogen levels and oestrogenic activity in adolescents with Type 1 diabetes compared with a healthy control group. We conducted a cross-sectional study that evaluated adolescents with Type 1 diabetes (n = 38) and healthy adolescents (control group; n = 32). Serum oestrogens, urinary oestrogen metabolites and serum oestrogenic activity were assessed. Oestrogenic activity was evaluated in an in vitro cell proliferation assay using a modified E-screen assay with MCF-7/BUS cells. Adolescents with Type 1 diabetes had lower oestrogenic activity levels in both phases of the menstrual cycle compared with the control group (follicular phase: 76 vs 94%; luteal phase: 97 vs 131%; P < 0.01), even after adjusting for BMI, oestradiol and oestrone levels. Postmenarcheal adolescents with Type 1 diabetes had lower oestradiol levels compared with control subjects in the follicular phase (63.3 pmol/l vs 89.4 pmol/l; P < 0.01) and higher oestrone levels compared with controls in the luteal phase (196 vs 151.9 pmol/l; P < 0.05). Adolescents with Type 1 diabetes had lower levels of serum oestrogenic activity, and these were lower than expected based on their serum oestradiol levels. We postulate that changes in the serum milieu of ...Continue Reading

References

Sep 1, 1995·Environmental Health Perspectives·M VillalobosV Pedraza
Oct 1, 1995·Environmental Health Perspectives·A M SotoF O Serrano
May 12, 2000·The Science of the Total Environment·J PayneA Kortenkamp
Jun 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica· Hoogenboom LAPA Brouwer
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Juan Carlos López-AlvarengaAlfredo Ulloa-Aguirre
Apr 28, 2005·The Journal of Clinical Endocrinology and Metabolism·Ethel CodnerFernando Cassorla
Jun 11, 2005·Science·Michael E Mendelsohn, Richard H Karas
Jan 31, 2006·Diabetes Care·Andrea SaloniaFrancesco Montorsi
Mar 20, 2008·The Journal of Clinical Endocrinology and Metabolism·Janet K Snell-BergeonMarian Rewers
Jul 2, 2008·Diabetes Care·Lucy D MastrandreaTeresa Quattrin
Dec 4, 2009·Journal of Diabetes and Its Complications·Néstor SotoEthel Codner
Jun 20, 2012·Human Reproduction Update·E CodnerM Tena-Sempere
Apr 17, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jue WangBrian L Sprague
Jun 8, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Kazutaka UedaRichard H Karas
Nov 10, 2013·Medical Hypotheses·Abarca-Rojano EdgarCampos-Rodríguez Rafael
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 28, 2014·Molecular and Cellular Endocrinology·A A Knowlton, D H Korzick
Apr 10, 2015·The Journal of Clinical Endocrinology and Metabolism·Nelly MaurasIan A Blair

❮ Previous
Next ❯

Citations

Aug 4, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alona FeldmanPhilippa Melamed
Sep 17, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·R I G Holt
Aug 28, 2017·Physiology & Behavior·Franck Mauvais-Jarvis
Sep 16, 2020·The Science of the Total Environment·Marta GeaTiziana Schilirò

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.