PMID: 9449249Aug 1, 1997Paper

Oestrogen control of the sexual dimorphism in the Harderian gland of Xenopus laevis

The Journal of Steroid Biochemistry and Molecular Biology
B Varriale, P Chieffi

Abstract

Xenopus laevis shows a sexual dimorphism of the electrophoretic pattern of Harderian gland (HG) proteins. The male pattern displays three protein fractions whose molecular sizes are approx. 205, 180 and 78 kDa, respectively, and which are absent in the female pattern. Conversely, the female pattern displays two protein fractions of approx. 190 and 76 kDa, respectively. This sexual dimorphism led us to hypothesize a sex steroid control of the HG. Administration of 17beta-oestradiol to male Xenopus converts the male protein pattern into the female one, while the administration of testosterone to the female has no effect. In this respect neither Northern analysis nor the RNase-protection assay performed using a 213 bp encoding for the androgen-binding domain reveals the presence of an androgen receptor mRNA in Xenopus HG. Conversely, Northern analysis has shown an oestrogen receptor mRNA whose size is approx. 6.5 kb and the RNase-protection assay performed by using a 197 bp encoding for the oestrogen-binding domain has also displayed the presence of an oestrogen receptor mRNA in the female HG but not in the male one. In addition, the oestrogen administration to male Xenopus induces the appearance of an oestrogen receptor mRNA. And...Continue Reading

References

Jul 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B VarrialeG Chieffi
May 1, 1991·The Journal of Endocrinology·M d'IstriaG Chieffi
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J H HohM J Nadakavukaren
Mar 1, 1982·The Anatomical Record·K ShiramaK Maekawa
Dec 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·B Varriale, I Serino
Aug 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J R TataK Yamauchi
Jan 1, 1996·International Review of Cytology·G ChieffiB Varriale
Nov 29, 1996·Molecular and Cellular Endocrinology·B VarrialeP Domínguez
May 1, 1996·Microscopy Research and Technique·G C Baccari

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Citations

Feb 9, 2010·Journal of Anatomy·Christine Nowack, Angela Wöhrmann-Repenning
Sep 8, 2015·The Journal of Steroid Biochemistry and Molecular Biology·T EspositoB Varriale

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