Oestrogen hormone receptors in focal nodular hyperplasia

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Manju D ChandrasegaramChristopher S Worthley

Abstract

The role of hormones in focal nodular hyperplasia (FNH) has been investigated with conflicting results. The aim of this study was to evaluate oestrogen and progesterone receptor immunohistochemical expression in FNH and surrounding normal liver (control material). Biopsy materials from FNH and control tissue were investigated using an immunostainer. Receptor expression was graded as the proportion score (percentage of nuclear staining) and oestrogen receptor intensity score. Study material included tissue from 11 resected FNH lesions and two core biopsies in 13 patients (two male). Twelve samples showed oestrogen receptor expression. The percentage of nuclear oestrogen receptor staining was <33% in eight FNH biopsies, 34-66% in two FNH biopsies, and >67% in both core biopsies. The better staining in core biopsies relates to limitations of the staining technique imposed by the fibrous nature of larger resected FNH. Control samples from surrounding tissue were available for nine of the resected specimens and all showed oestrogen receptor expression. Progesterone receptor expression was negligible in FNH and control samples. By contrast with previous studies, the majority of FNH and surrounding liver in this cohort demonstrated oe...Continue Reading

References

Feb 1, 1986·Journal of Clinical Pathology·P J Karhunen
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R WanlessR Adams
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D CherquiD Dhumeaux
Feb 26, 1999·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·L A HeinemannT DoMinh
Mar 4, 2000·Gastroenterology·D MathieuD Dhumeaux
Jun 20, 2001·The British Journal of Surgery·C K CharnyL H Blumgart
Oct 3, 2001·Journal of Hepatology·J HardwigsenY P Le Treut
Feb 21, 2002·American Journal of Obstetrics and Gynecology·Astrid ScaloriMassimo Colombo
Feb 11, 2004·American Journal of Surgery·Frederick C Cobey, Ronald R Salem
Jul 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Joseph KimAndrew M Lowy
Nov 20, 2004·Ultrasound in Medicine & Biology·Elisabetta BuscariniAlessandro Zambelli
Jan 31, 2007·Annals of the New York Academy of Sciences·L GiannitrapaniG Montalto
Apr 2, 2010·Digestive Surgery·Lucas Maillette de Buy WennigerUlrich Beuers
Aug 31, 2010·Future Oncology·Elia PulvirentiIsidoro Di Carlo
Nov 1, 2012·Scandinavian Journal of Gastroenterology·Kinan RifaiMichael J Gebel
Jun 29, 2013·Updates in Surgery·Agustin CristianoEduardo de Santibañes

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Citations

Dec 26, 2015·Journal of Pediatric Gastroenterology and Nutrition·Yi JiLi Li
Dec 21, 2017·Abdominal Radiology·Federica VernuccioValérie Vilgrain
Oct 17, 2019·Journal of Surgical Case Reports·Andreea BenteKristen M Glasgow
Jan 19, 2021·ACG Case Reports Journal·Ashraf A AshhabWalid S Ayoub
Oct 3, 2020·Visceral Medicine·Karl J OldhaferKim Caroline Wagner

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