Oestrogen Receptor β Activation Protects Against Myocardial Infarction via Notch1 Signalling

Cardiovascular Drugs and Therapy
Mingjun DuSong Xue

Abstract

Oestrogen receptor β is believed to exert a cardioprotective effect against ischaemic injury. Nonetheless, the mechanism underlying its protective action remains to be fully elucidated. Recently, increased attention has been focused on Notch1 signalling for ameliorating cardiac ischaemic injury. Here, we hypothesised that oestrogen receptor β activation attenuates myocardial infarction (MI)-induced cardiac damage by modulating the Notch1 signalling pathway. Male C57BL/6 mice were used to establish an MI model through the ligation of the anterior descending branch of the left coronary artery. Two chemical drugs, 2,3-Bis(4-hydroxyphenyl)-propionitrile (DPN) and N-[N-(3,5-difluorophenacetyl)-l-alanyl]-s-phenylglycine t-butyl ester (DAPT), a specific inhibitor of Notch1 signalling) were administered via intraperitoneal injection to change oestrogen receptor β and Notch1 activities. Immunohistochemistry, western blot analysis, enzyme-linked immunosorbent assay (Elisa) assessment and echocardiography were used in this study to analyse cardiac oxidative stress, apoptosis, infraction volume, fibrosis and cardiac function. DPN-mediated oestrogen receptor β activation effectively protected cardiomyocytes from MI-induced oxidative damage ...Continue Reading

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Citations

Sep 19, 2020·Biomarker Research·Yujing Zhou, Xingdang Liu
Feb 15, 2021·International Immunopharmacology·Zheng WuJinghua Liu
Oct 16, 2020·Basic Research in Cardiology·M V BasalayS M Davidson
Jan 13, 2021·International Journal of Molecular Sciences·Jaqueline S da SilvaGisele Zapata-Sudo

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
immunoprecipitation assay
protein assay
MDA
transgenic

Software Mentioned

ImageJ
SPSS

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