Oestrogen receptor gene (ESR1) amplification is frequent in endometrial carcinoma and its precursor lesions.

The Journal of Pathology
A LebeauR Simon

Abstract

Oestrogen receptor alpha (ER) plays a critical, diverse and not fully understood role in endometrial carcinoma. Most endometrial carcinomas express ER and some of these tumours respond favourably to anti-oestrogen therapy. On the other hand, tamoxifen therapy constitutes a major risk factor for endometrial carcinoma development. Amplification of the ESR1 gene encoding ER was recently shown to constitute a mechanism for ER over-expression in breast carcinoma. This study was designed to determine the potential role of ESR1 amplifications in endometrial carcinoma. Tissue microarrays of 368 endometrial carcinomas and large sections of 43 cases of endometrial hyperplasia were analysed for ESR1 gene amplification and ER protein expression by means of fluorescence in situ hybridization (FISH) and immunohistochemistry. FISH revealed ESR1 amplification in 40/176 (23%) cancers, 6/19 (32%) atypical complex hyperplasias, 3/10 (30%) complex hyperplasias without atypia and 2/14 (14%) simple hyperplasias without atypia. Strong ER protein expression was significantly linked to ESR1 amplification in endometrial carcinoma (p = 0.0036). These data indicate that ESR1 amplification might be one mechanism for ER over-expression in endometrial carcin...Continue Reading

References

Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·S S IngramM Varia
Apr 1, 1988·American Journal of Obstetrics and Gynecology·C E EhrlichW M Alford
Jan 1, 1988·Acta Obstetricia Et Gynecologica Scandinavica·O E IversenE Skaarland
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M HarveyD C Allred
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T ThigpenJ Bell
Jun 16, 2001·Virchows Archiv : an International Journal of Pathology·E SivridisP Anastasiadis
Jan 25, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Marika J Linja, Tapio Visakorpi
Jun 2, 2006·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists Committee on Gynecologic Practice
Jun 13, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H Kitchener
Feb 9, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J FerlayP Boyle
Apr 10, 2007·Nature Genetics·Frederik HolstRonald Simon

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Citations

Jun 1, 2012·Archives of Toxicology·Katherine A Burns, Kenneth S Korach
Oct 25, 2011·Nature Reviews. Cancer·Ke-Da Yu, Zhi-Ming Shao
Jan 12, 2011·Nature Reviews. Clinical Oncology·Konstantin J DedesJorge S Reis-Filho
Aug 16, 2015·Molecular and Cellular Endocrinology·Michelle M BoisenSteffi Oesterreich
Sep 13, 2008·The Journal of Pathology·D S P TanJ S Reis-Filho
May 31, 2014·Investigational New Drugs·Charng Choon WongJohnson Stanslas
Dec 17, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Enora LaasOlivier Graesslin
Apr 16, 2016·World Journal of Clinical Oncology·Frederik Holst
Jul 25, 2018·International Journal of Molecular Sciences·Alessandro La FerlitaCinzia Di Pietro
Apr 19, 2019·International Journal of Molecular Sciences·Anna NagelAleksandra Markiewicz
Mar 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Athanassios DellasHolger Moch
Mar 21, 2021·Journal, Genetic Engineering & Biotechnology·Rakibul IslamMohammad Ali Moni
May 16, 2014·Genome Research·Elena HelmanMatthew Meyerson

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