Oestrogen receptors enhance dopamine neurone survival in rat midbrain.

Journal of Neuroendocrinology
Misha JohnsonCynthia M Kuhn

Abstract

Previous findings in our laboratory and elsewhere have shown that ovariectomy of rats in adulthood attenuates cocaine-stimulated locomotor behaviour. Ovarian hormones enhance both cocaine-stimulated behaviour and increase dopamine overflow after psychomotor stimulants. The present study aimed to determine whether ovarian hormones have these effects in part by maintaining dopamine neurone number in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) and to investigate the roles of specific oestrogen receptors (ERs) in the maintenance of mesencephalic dopamine neurones. To accomplish this goal, we used unbiased stereological techniques to estimate the number of tyrosine hydroxylase-immunoreactive (TH-IR) cell bodies in midbrain regions of intact, ovariectomised and hormone-replaced female rats and mice. Animals received active or sham gonadectomy on postnatal day 60 and received vehicle, 17beta-oestradiol (E(2)) or selective ER agonists propyl-pyrazole-triol (PPT, ERalpha) or diarylpropionitrile (DPN, ERbeta) for 1 month post-surgery. In both rats and mice, ovariectomy reduced the number of TH-IR cells in the SNpc and VTA. Replacement with E(2), PPT or DPN prevented or attenuated the loss observed with ovar...Continue Reading

References

Jan 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A S Tischler
Jan 1, 1994·Reviews in the Neurosciences·T Di Paolo
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Dec 5, 1997·The Journal of Comparative Neurology·P J ShughrueI Merchenthaler
Jul 21, 1998·Annals of the New York Academy of Sciences·D B MillerS C Laws
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H KregeO Smithies
May 5, 1999·Neurology·R Saunders-PullmanS Bressman
Jul 1, 1999·The Psychiatric Clinics of North America·K T Brady, C L Randall
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J B Becker
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L WangJ A Gustafsson
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Q D WalkerC M Kuhn
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·M D BenedettiW A Rocca
Jan 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ling WangJan-Ake Gustafsson
Jan 30, 2003·Journal of Neurobiology·Tatiana Ivanova, Cordian Beyer
Sep 6, 2003·The European Journal of Neuroscience·D StanicM K Horne
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·G F WootenJ Patrie
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·H V O CarswellK J Horsburgh
Nov 6, 2004·Neuroscience and Biobehavioral Reviews·Megan E RothMarilyn E Carroll
Nov 24, 2004·Hormones and Behavior·Eugene D Festa, Vanya Quinones-Jenab
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Q David WalkerCynthia M Kuhn
Nov 29, 2005·Neuropharmacology·Maryvonne Le SauxThérèse Di Paolo
Feb 3, 2006·Journal of Neuroendocrinology·M Le Saux, T Di Paolo
Mar 1, 2006·Experimental and Clinical Psychopharmacology·Wendy J Lynch
Jun 21, 2006·Endocrine·Gloria E HoffmanSusan L Zup
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Simon McArthurGlenda E Gillies

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Citations

Sep 15, 2012·Psychopharmacology·Amanda E D Van SwearingenCynthia M Kuhn
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary P HeyerGuoping Feng
Jan 15, 2014·Journal of Chemical Neuroanatomy·Geraldine K E GoebrechtJ Matthew Kittelberger
Feb 11, 2014·Experimental Neurology·Samara A M BobzeanLinda I Perrotti
Sep 13, 2011·Appetite·Caroline DavisJames L Kennedy
Nov 11, 2009·Hormones and Behavior·Cynthia KuhnQ David Walker
Jul 24, 2013·Journal of Neuroendocrinology·K S J ErvinE Choleris
Feb 9, 2010·Journal of Neuroendocrinology·M L JohnsonC M Kuhn
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Caroline DavisJames L Kennedy
Dec 3, 2014·Pharmacology, Biochemistry, and Behavior·F SchneiderK G Reymann
Mar 10, 2018·American Journal of Epidemiology·Marie-Pierre SylvestreJennifer O'Loughlin
Feb 18, 2016·Medicine and Science in Sports and Exercise·Young-Min ParkVictoria J Vieira-Potter
Sep 24, 2019·Endocrine Reviews·Elisabetta VegetoAngelo Poletti
Jun 9, 2020·Frontiers in Behavioral Neuroscience·Saurabh S Kokane, Linda I Perrotti
Dec 10, 2015·American Journal of Physiology. Endocrinology and Metabolism·Young-Min ParkVictoria J Vieira-Potter
Aug 25, 2017·Scientific Reports·Tzu-Wen L CrossVictoria J Vieira-Potter
Nov 22, 2016·Journal of Neuroscience Research·Sarah J CrossFrances M Leslie

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