Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy

British Journal of Cancer
R A McClellandR I Nicholson

Abstract

Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy.

Citations

Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·Grit KasperKerstin Lehmann
Aug 2, 2012·Nutrients·Bruce J Grattan, Hedley C Freake
Sep 5, 2019·Metallomics : Integrated Biometal Science·Silvia ZiliottoKathryn M Taylor
Dec 1, 2017·Nutrients·Inga WesselsLothar Rink
Apr 30, 2009·Annual Review of Nutrition·Louis A Lichten, Robert J Cousins
Mar 28, 2003·Biochimica Et Biophysica Acta·Kathryn M Taylor, Robert I Nicholson
Aug 29, 2021·Breast Cancer Research and Treatment·Maryam AlthobitiEmad A Rakha

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