PMID: 1466154Jan 1, 1992Paper

Oestrogen retards the development of spontaneous thymomas in BUF/Mna rats

Virchows Archiv. A, Pathological Anatomy and Histopathology
T EzakiM Kotani

Abstract

BUF/Mna rats develop spontaneous thymomas with nearly 100% incidence in both sexes. While the thymomas in males develop from around 9 months of age, those in females start from 13-15 months of age. To clarify the mechanism of the delay of thymomagenesis in females, the effect of sex hormones on the development of thymomas was examined after either gonadectomy or oestrogen treatment. Prepubertal ovariectomy accelerated the thymoma development in females, whereas orchiectomy did not affect it. An intraperitoneal injection of oestriol (20 mg) into males at 2 months of age remarkably diminished the thymic weight to about one-tenth of age-matched controls at 16 months of age. These results suggest that oestrogen can actually retard the onset of thymoma in spite of genetic control of its incidence. However, oestrogen did not cause thymic involution when it was injected into rats over 9 months of age. Immunohistochemically, there seemed to be no distinct difference in distribution of oestrogen-receptor-bearing epithelial cells between thymomas and 2- to 3-month-old thymuses. The oestrogen sensitivity of the thymus might be destined to be lost, as the thymic epithelial cells start neoplastic changes with the impairment of oestrogen-rec...Continue Reading

References

Dec 19, 1979·Biochimica Et Biophysica Acta·D P EdwardsW L McGuire
Sep 1, 1979·Journal of Steroid Biochemistry·C J GrossmanP Nathan
Jun 1, 1977·Journal of the National Cancer Institute·S M Hinsull, D Bellamy
Dec 1, 1975·Journal of the National Cancer Institute·A Maekawa, S Odashima
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K HirokawaE Moriizumi
Jan 1, 1990·Pharmacology & Therapeutics·J E Hart
Jan 1, 1990·Archives of Histology and Cytology·M Kotani
Apr 1, 1989·British Journal of Cancer·R KawatsuM Akagi
Sep 1, 1988·Japanese Journal of Cancer Research : Gann·M MatsuyamaA Kojima
Jan 1, 1969·International Review of Cytology·B Vernon-Roberts
Apr 1, 1984·Archives of Internal Medicine·E C Rosenow, B T Hurley
Dec 1, 1982·Journal of Pharmacobio-dynamics·F Kato, M Watanabe
Oct 1, 1952·Physiological Reviews·T F DOUGHERTY

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Citations

Dec 17, 2011·Autoimmunity Reviews·Tai-Ping Lee, Bor-Luen Chiang
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Hironori IshibashiHironobu Sasano

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