Abstract
It is no surprise to anyone who has tried to memorize clotting and complement cascades that there are a great many trypsin-like proteases-too many, it may seem. This fecund enzyme family encompasses such a range of biological roles that other important members and functions are sure to await discovery. Of known trypsin-like proteases, few, if any, are lung-specific. Nonetheless, many contribute in ways critical to lung function, such as fighting microbial invaders, regulating the formation and removal of polymerized fibrin, and rejecting tumors or transplanted tissues. Some of these enzymes, such as plasminogen activators and mast cell tryptases, are native to the lung and live where they work; identical enzymes live and work in other tissues. Other enzymes, such as most complement and hemostatic proteases, are migrants, typically born elsewhere (e.g., the liver). They pass through the lung, looking for something to do; if nothing is found, they pass on, circulating, perhaps to return later. Still others are unwanted, uninvited intruders, such as dust mite proteases. This minireview provides a selective glimpse of the lives of some of the trypsin-like enzymes at work in the lung and airways.
Citations
Nov 13, 2003·European Journal of Pharmacology·Sela Mager, Jennifer Sloan
Jan 23, 1999·Current Opinion in Immunology·T A Platts-MillsR C Aalberse
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D SotoG H Caughey
Nov 16, 2007·International Archives of Allergy and Immunology·Enrique Fernández-CaldasVictor Iraola
Aug 21, 2007·BMC Immunology·Ricardo SabanMarcia R Saban
Aug 9, 2005·FEBS Letters·Marta ArtiedaFernando Civeira
Apr 24, 2012·Cellular Immunology·Masaki KawakamiNaomi Yamashita
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S M BelkowskiM R D'Andrea
Apr 28, 2001·Chemistry & Biology·N SchaschkeL Moroder
Oct 4, 2016·International Immunopharmacology·Jatinder SinghDhandeep Singh
Jan 4, 2017·International Archives of Allergy and Immunology·Siju GaoZhaoan Wang
Apr 18, 2002·Bioorganic & Medicinal Chemistry Letters·Norbert SchaschkeChristian P Sommerhoff
Dec 14, 2004·Chembiochem : a European Journal of Chemical Biology·Norbert SchaschkeChristian P Sommerhoff
Aug 11, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Thomas G Brock, Camillo Di Giulio
Apr 1, 1998·Nature·P J PereiraW Bode
Mar 22, 2003·Expert Review of Molecular Diagnostics·Marcia R SabanRicardo Saban
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer L SloanSela Mager
Nov 26, 2002·Immunological Reviews·Pierre Van Der BruggenThierry Boon
Aug 5, 1998·The American Journal of Physiology·G H CaugheyK C Fang
Jan 28, 1999·The Journal of Biological Chemistry·M PallaoroG H Caughey
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·C P SommerhoffA Bergner
Jan 18, 2018·Scandinavian Journal of Immunology·T IshiiN Yamashita
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Se-Woong OhWilliam R Henderson
Jan 17, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·James K BrownIan P Hall
Nov 21, 2002·The Journal of Biological Chemistry·Vikash J BhagwandinGeorge H Caughey
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G H CaugheyG M Verghese
Mar 10, 2000·Biochimica Et Biophysica Acta·C P SommerhoffH Fritz
Aug 22, 2003·Journal of Medicinal Chemistry·Michael J CostanzoBruce E Maryanoff
Sep 8, 2004·Bioorganic & Medicinal Chemistry·Tommaso MeccaFrancesca Cunsolo
Dec 4, 2003·Biochemistry·Annett RozekRobert E W Hancock
Feb 6, 2004·Journal of Medicinal Chemistry·Bruce E Maryanoff