OFF-cholinergic-pathway-selective localization of P2X2 purinoceptors in the mouse retina

The Journal of Comparative Neurology
Makoto KanedaTsutomu Hashikawa

Abstract

It is known that, in the retina, extracellular adenosine triphosphate (ATP) inhibits acetylcholine (ACh) release from cholinergic neurons, but the types of purinoceptors on cholinergic neurons have not been examined. In the present work, we immunohistochemically examined the distribution of the purinoceptors P2X1, P2X2, P2X4, and P2X7 in relation to the cholinergic system of the retina in wild-type mice and transgenic mice expressing green fluorescent protein (GFP). Immunoreactivity for P2X2 was very strong in sublamina a of the inner plexiform layer but very weak in sublamina b of the inner plexiform layer of the retina. Immunoreactivity for P2X2 was colocalized with that for choline acetyltransferase (ChAT). When transgenic mice were treated with the immunotoxin-mediated cell-targeting technology to ablate cholinergic amacrine cells selectively, immunoreactivity for P2X2 and the signals for GFP disappeared in parallel and selectively in the OFF pathway. The distribution of immunoreactivity for P2X1, P2X4, and P2X7 differed from that of ChAT immunoreactivity. The selective distribution of P2X2 purinergic receptors in OFF-type cholinergic amacrine cells indicates that the P2X2 purinergic signaling systems in the ON and OFF path...Continue Reading

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Citations

May 19, 2005·Journal of Molecular Histology·Makoto KanedaTsutomu Hashikawa
Jul 3, 2007·Journal of Molecular Histology·Yasuhide ShigematsuMakoto Kaneda
Aug 3, 2013·Journal of Molecular Histology·Rai DilipMakoto Kaneda
Jan 28, 2014·Acta histochemica·Lily Alexandrova Vitanova, Petia Nikolova Kupenova
Aug 3, 2014·The Journal of Physiology·Toshiyuki Ishii, Makoto Kaneda
Oct 13, 2009·Neuroscience Research·Makoto KanedaYukio Shimoda
Feb 24, 2009·Trends in Neurosciences·Gary D HousleyAndreas Reichenbach
Feb 19, 2009·Neuroscience·M M Ward, E L Fletcher
Oct 27, 2015·Frontiers in Cellular Neuroscience·Tracy HoKirstan A Vessey
Jul 12, 2008·The European Journal of Neuroscience·Makoto KanedaToshihiko Hosoya
Dec 26, 2009·Brain Research·Tiago de Oliveira Simões PereiraPaulo Fernando Martins dos Santos
Mar 9, 2013·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Makoto Kaneda
Oct 19, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Tracy HoErica L Fletcher
Sep 27, 2016·Neuron·Ivan TochitskyRichard H Kramer
Jul 14, 2017·Journal of Neurophysiology·Toshiyuki IshiiMakoto Kaneda
Feb 7, 2018·The Journal of Comparative Neurology·Chi ZhangRachel O L Wong
Apr 15, 2006·The Journal of Comparative Neurology·Theresa Puthussery, Erica L Fletcher
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Apr 13, 2007·Journal of Neurophysiology·Makoto KanedaYukio Shimoda
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Apr 18, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Almudena CrookeJesus Pintor
Mar 20, 2008·Current Eye Research·Sylvia SarmanJuan E Gallo

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