Off-label biologic therapy of ANCA-associated and non-ANCA-associated small-vessel vasculitis : Efficacy and safety analysis of a national registry (GRAID2)

Zeitschrift für Rheumatologie
N VenhoffJ Thiel

Abstract

To evaluate the clinical efficacy and safety of off-label biological therapies in patients with ANCA-associated vasculitis (AAV) and non-ANCA-associated small-vessel vasculitis (nAAV) in clinical practice. The German Registry in Autoimmune Diseases 2 (GRAID2) is a national, retrospective, non-interventional, multicentre observational study (August 2006 until December 2013) on patients with autoimmune diseases refractory to standard immunosuppressive therapy treated with off-label biologicals. Data from 64 patients (20.6% of all GRAID2 patients) were collected: 54 patients (84.4%) had ANCA-associated vasculitis (AAV) and 10 patients (15.6%) had non-ANCA-associated small-vessel vasculitis (nAAV). Of the AAV patients, 96.3% were treated off-label with rituximab (RTX) and 3.7% with tumor necrosis factor alpha (TNFα)-inhibitors. Of patients with nAAV, 30% were treated with RTX, 60% with TNFα-inhibitors, and 10% with tocilizumab. The main reasons for off-label biological treatment in AAV patients were pulmonary, renal, or ear, nose, and throat involvement. These manifestations clearly improved in most patients after off-label biological therapy was initiated. Daily glucocorticoid dosage could be reduced. The off-label biological ther...Continue Reading

References

Aug 2, 1979·The New England Journal of Medicine·A S FauciS M Wolff
Jul 22, 2010·The New England Journal of Medicine·John H StoneUNKNOWN RAVE-ITN Research Group
Nov 10, 2010·JAMA : the Journal of the American Medical Association·Thomas F HiemstraUNKNOWN European Vasculitis Study Group (EUVAS)
Aug 2, 2013·The New England Journal of Medicine·Ulrich SpecksUNKNOWN RAVE-ITN Research Group
Jul 23, 2014·Arthritis & Rheumatology·E M MiloslavskyUNKNOWN Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group
Nov 6, 2014·The New England Journal of Medicine·Loïc GuillevinUNKNOWN French Vasculitis Study Group

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