Off-label intranasal oxytocin use in adults is associated with increased amygdala-cingulate resting-state connectivity

European Psychiatry : the Journal of the Association of European Psychiatrists
B Kovács, S Kéri

Abstract

Intranasally administered oxytocin gained popularity as a hormone facilitating trust, cooperation, and affiliation. However, the long-term consequences of oxytocin use are not known. Given that intensive media attention and advertisements of the "love hormone" might lead to a new form of misuse, we conducted an online survey and identified 41 individuals with oxytocin misuse. Misuse will be proposed throughout the manuscript instead of the more accurate "off-label use" for reasons of simplicity. We compared the social functions of oxytocin users with that of 41 matched control volunteers. We administered the "Reading the Mind in the Eyes Test" (RMET) and the National Institute of Health (NIH) Toolbox Adult Social Relationship Scales (NIH-ASRS) to delineate affective "theory of mind" and real-life social functions, respectively. Resting-state functional brain connectivity analyses were also carried out. Results revealed no significant differences between individuals with oxytocin misuse and control participants on the RMET and NIH-ASRS. However, individuals with oxytocin misuse showed an increased connectivity between the right amygdala and dorsal anterior cingulate cortex relative to the control group. Higher estimated cumulati...Continue Reading

References

Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Jan 1, 1994·Psychoneuroendocrinology·Z Sarnyai, G L Kovács
Mar 31, 2001·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Baron-CohenI Plumb
Jun 3, 2005·Nature·Michael KosfeldErnst Fehr
Oct 5, 2005·PLoS Computational Biology·Olaf SpornsRolf Kötter
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter KirschAndreas Meyer-Lindenberg
Dec 2, 2006·Biological Psychiatry·Gregor DomesSabine C Herpertz
Jul 10, 2007·Biological Psychiatry·Gregor DomesSabine C Herpertz
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
May 3, 2008·Urologic Oncology·Bruce J Trock
Jun 27, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Predrag PetrovicRaymond J Dolan
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
Jun 10, 2009·Frontiers in Neuroendocrinology·Markus HeinrichsGregor Domes
Aug 15, 2009·Cognitive, Affective & Behavioral Neuroscience·Szabolcs Kéri, György Benedek
Nov 10, 2009·Biological Psychiatry·Adam J GuastellaIan B Hickie
Mar 25, 2010·Annual Review of Neuroscience·C Daniel Salzman, Stefano Fusi
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthias GamerChristian Büchel
Jun 30, 2010·Journal of Affective Disorders·Waguih William IshakHala Fakhry
Jul 10, 2010·Biological Psychiatry·David FeifelAllison Hadley
Mar 25, 2011·Psychoneuroendocrinology·Elayne MacDonaldAvril J Cauchi
Jun 24, 2011·Trends in Cognitive Sciences·Jennifer A BartzKevin N Ochsner
Jul 1, 2011·Social Neuroscience·Greg J NormanJohn T Cacioppo
Dec 27, 2011·Hormones and Behavior·Patricia S Churchland, Piotr Winkielman
Feb 9, 2012·Trends in Cognitive Sciences·Mathieu RoyTor D Wager
May 31, 2012·Brain Connectivity·Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon
Jun 1, 2012·The International Journal of Neuropsychopharmacology·Chandra Sekhar SripadaAmanda G Wood
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin C BickartBradford C Dickerson
Nov 20, 2012·Psychoneuroendocrinology·Richard A I BethlehemSimon Baron-Cohen
Feb 27, 2013·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Jill M CyranowskiDavid Cella
May 8, 2013·Neuroscience and Biobehavioral Reviews·Jan G Veening, Berend Olivier
Aug 29, 2013·The American Journal of Psychiatry·Katja BertschSabine C Herpertz

❮ Previous
Next ❯

Citations

Apr 1, 2016·Psychoneuroendocrinology·Natalie C EbnerRonald A Cohen
Dec 14, 2017·Nature Communications·Marc T PisanskyJonathan C Gewirtz
Jan 20, 2020·Brain Imaging and Behavior·Haiyan WuQuanying Liu
Oct 9, 2018·American Journal of Primatology·Lisa A ParrErin Hecht
Mar 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kaat AlaertsNicole Wenderoth
May 28, 2019·Neuroscience and Biobehavioral Reviews·E R VelascoR Andero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.