Off-pump coronary surgery causes immediate release of myocardial damage markers

Asian Cardiovascular & Thoracic Annals
Inga KaruJoel Starkopf

Abstract

Off-pump coronary surgery does not eliminate the risks of ischemia-reperfusion injury. The main objective of this study was to describe the extent and time course of changes in myocardial metabolism and development of myocardial injury associated with revascularization. Coronary sinus and arterial blood samples for measurement of troponin I, creatine kinase MB, lactate, glutathione, and interleukin-6 were taken from 23 patients prior to grafting, after completion of each anastomosis, and up to the 1st postoperative morning. The results were evaluated together with parameters of cardiac function. Release of lactate, creatinine kinase MB, and troponin I into the coronary sinus was evident after completion of the 1st graft, and increased over time. During the procedure, only trace amounts of oxidized and reduced glutathione were detected in coronary sinus and arterial blood. Significant increases in interleukin-6 were found in coronary sinus samples after 5 and 20 min of reperfusion. Surgical trauma during off-pump coronary surgery is sufficient to activate an inflammatory response in the myocardium, together with unfavorable metabolic conditions to cause myocardial necrosis.

References

Sep 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·S WanJ L LeClerc
Aug 26, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A K TassiopoulosD J McGraw
Oct 13, 1998·The Annals of Thoracic Surgery·B L BufkinR A Guyton
May 23, 2002·The Annals of Thoracic Surgery·Mark YeatmanGianni D Angelini
Apr 12, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Stephen L GutheryJames E Heubi
Apr 10, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Michael C FishbeinFred S Apple
Oct 24, 2007·European Heart Journal·Kristian ThygesenUNKNOWN Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction

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Citations

Feb 10, 2010·Scandinavian Cardiovascular Journal : SCJ·Inga KaruMihkel Zilmer
Nov 12, 2015·Journal of Cardiothoracic Surgery·Haralabos ParissisBassel Al-Alao
Aug 10, 2016·World Journal of Surgery·Miriam KalbitzMarkus Huber-Lang
Oct 19, 2013·Experimental and Therapeutic Medicine·Jianjun RenZhenming Dong

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Methods Mentioned

BETA
coronary artery bypass

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