Off-resonance NOVEL

The Journal of Chemical Physics
Sheetal JainR G Griffin

Abstract

Dynamic nuclear polarization (DNP) is theoretically able to enhance the signal in nuclear magnetic resonance (NMR) experiments by a factor γe/γn, where γ's are the gyromagnetic ratios of an electron and a nuclear spin. However, DNP enhancements currently achieved in high-field, high-resolution biomolecular magic-angle spinning NMR are well below this limit because the continuous-wave DNP mechanisms employed in these experiments scale as ω0-n where n ∼ 1-2. In pulsed DNP methods, such as nuclear orientation via electron spin-locking (NOVEL), the DNP efficiency is independent of the strength of the main magnetic field. Hence, these methods represent a viable alternative approach for enhancing nuclear signals. At 0.35 T, the NOVEL scheme was demonstrated to be efficient in samples doped with stable radicals, generating 1H NMR enhancements of ∼430. However, an impediment in the implementation of NOVEL at high fields is the requirement of sufficient microwave power to fulfill the on-resonance matching condition, ω0I = ω1S, where ω0I and ω1S are the nuclear Larmor and electron Rabi frequencies, respectively. Here, we exploit a generalized matching condition, which states that the effective Rabi frequency, ω1Seff, matches ω0I. By usin...Continue Reading

References

Nov 22, 1993·Physical Review Letters·L R BecerraR G Griffin
Sep 10, 1999·Journal of Magnetic Resonance·V WeisR G Griffin
Jan 15, 2005·Journal of Magnetic Resonance·M K BowmanH J Halpern
Nov 22, 2005·Solid State Nuclear Magnetic Resonance·V Weis, R G Griffin
Oct 10, 2006·Journal of Magnetic Resonance·Thorsten MalyRobert G Griffin
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Melody L Mak-JurkauskasJudith Herzfeld
Feb 13, 2008·The Journal of Chemical Physics·Thorsten MalyRobert G Griffin
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Vikram S BajajRobert G Griffin
Apr 30, 2010·Physical Chemistry Chemical Physics : PCCP·Robert I HunterGraham M Smith
May 8, 2010·Physical Chemistry Chemical Physics : PCCP·Melanie RosayWerner E Maas
Jun 3, 2010·Physical Chemistry Chemical Physics : PCCP·Yoh MatsukiToshimichi Fujiwara
Sep 14, 2010·Journal of the American Chemical Society·Anne LesageLyndon Emsley
Nov 19, 2010·Journal of Magnetic Resonance·Yonatan HovavShimon Vega
Nov 19, 2010·Nature·Robert G Griffin
Feb 24, 2011·The Journal of Chemical Physics·Yonatan HovavShimon Vega
Mar 31, 2011·Journal of the American Chemical Society·Björn CorziliusRobert G Griffin
Apr 5, 2011·The Journal of Chemical Physics·Kan-Nian HuRobert G Griffin
Jul 22, 2011·Journal of the American Chemical Society·Marvin J BayroRobert G Griffin
Jan 14, 2012·The Journal of Chemical Physics·Albert A SmithRobert G Griffin
Jan 21, 2012·Physical Chemistry Chemical Physics : PCCP·Alexander KarabanovWalter Köckenberger
May 15, 2012·Journal of Magnetic Resonance·Philipp E SpindlerThomas F Prisner
Aug 17, 2012·The Journal of Chemical Physics·Björn CorziliusRobert G Griffin
Sep 15, 2012·Journal of Magnetic Resonance·Albert A SmithRobert G Griffin
Sep 25, 2012·Journal of Magnetic Resonance·Alexander B BarnesRobert G Griffin
Nov 20, 2012·Physical Chemistry Chemical Physics : PCCP·Yonatan HovavShimon Vega
Dec 15, 2012·Chemical Communications : Chem Comm·Olivier LafonJean-Paul Amoureux
Mar 23, 2013·Accounts of Chemical Research·Aaron J RossiniLyndon Emsley
Jun 1, 2013·Journal of Magnetic Resonance·S N TrukhanO N Martyanov
Dec 5, 2013·Chemical Communications : Chem Comm·Frédérique PourpointJean-Paul Amoureux
Jan 31, 2014·Physical Review Letters·E A NanniR J Temkin
May 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kenichiro TateishiMasahiro Kitagawa
Jul 27, 2014·Journal of Magnetic Resonance·Andrin Doll, Gunnar Jeschke
Mar 24, 2015·Journal of Magnetic Resonance·T V CanR G Griffin
Jul 30, 2015·Journal of Biomolecular NMR·Patricia WenkBjörn Corzilius
Aug 10, 2015·The Journal of Chemical Physics·T V CanR G Griffin
Sep 15, 2015·Physical Chemistry Chemical Physics : PCCP·Alicia LundSong-I Han
Oct 17, 2015·Journal of the American Chemical Society·Laura PiveteauMaksym V Kovalenko
Oct 21, 2015·Solid State Nuclear Magnetic Resonance·Daniel E M HoffAlexander B Barnes
Dec 15, 2015·The Journal of Physical Chemistry Letters·Guinevere MathiesRobert G Griffin
Feb 28, 2016·Journal of Magnetic Resonance·Melanie RosayFrank Engelke

❮ Previous
Next ❯

Citations

Oct 31, 2018·Physical Chemistry Chemical Physics : PCCP·Alisa LeavesleySongi Han
Feb 13, 2019·Science Advances·Kong Ooi TanRobert G Griffin
Jul 31, 2019·Science Advances·Kong Ooi TanRobert G Griffin
Feb 20, 2020·Annual Review of Physical Chemistry·Björn Corzilius
Oct 27, 2020·Physical Chemistry Chemical Physics : PCCP·Jörg HeiligerBjörn Corzilius
Jul 23, 2019·Journal of Magnetic Resonance·Robert G GriffinRichard J Temkin
Aug 5, 2018·Journal of Magnetic Resonance·Erika L SestiAlexander B Barnes
Feb 23, 2018·Journal of Magnetic Resonance·Faith J ScottAlexander B Barnes
Apr 7, 2019·Journal of Magnetic Resonance·Armin PureaFrank Engelke
Jun 13, 2019·Solid State Nuclear Magnetic Resonance·Andrew G M RankinOlivier Lafon
Jun 30, 2021·Journal of Magnetic Resonance·T V CanR G Griffin
Dec 4, 2019·The Journal of Physical Chemistry Letters·Asif EqubalSongi Han
May 15, 2018·The Journal of Physical Chemistry Letters·T V CanR G Griffin
Sep 6, 2018·The Journal of Physical Chemistry Letters·Edward P SalibaAlexander B Barnes
Jan 16, 2019·The Journal of Physical Chemistry Letters·Asif EqubalSongi Han
Nov 25, 2021·The Journal of Physical Chemistry. B·Georges MenzildjianAnne Lesage
Jan 26, 2022·Journal of the American Chemical Society·Venkata SubbaRao Redrouthu, Guinevere Mathies
Feb 1, 2022·Chemical Reviews·Thomas BiedenbänderBjörn Corzilius

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Angewandte Chemie
Thach V CanR G Griffin
The Journal of Chemical Physics
T V CanR G Griffin
The Journal of Physical Chemistry Letters
Guinevere MathiesR G Griffin
© 2022 Meta ULC. All rights reserved