PMID: 9543421Apr 16, 1998Paper

Off-resonance proton T1rho dispersion imaging of 17O-enriched tissue phantoms

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Sridhar R CharagundlaRavinder Reddy

Abstract

Proton T1rho dispersion imaging is a recently described method for indirect detection of 17O. However, clinical implementation of this technique is hindered by the requirement for a high-amplitude spin-locking field (gammaB1 > 1 kHz) that exceeds current limitations in specific absorption rate (SAR). Here, a strategy is offered for circumventing high SAR in T1rho dispersion imaging of 17O through the use of low-amplitude off-resonance spin-locking pulses (gammaB1 < 300 Hz). Proton spin-lattice relaxation times in the off-resonance rotating frame were measured in H2(17)O-enriched tissue phantoms. On- and off-resonance T1rho dispersion imaging was implemented at 2 T using a spin-locking preparatory pulse cluster appended to a standard spin-echo sequence. On- and off-resonance dispersion images exhibited similar 17O-based image contrast. Magnetization transfer effects did not depend on 17O concentration and had no effect on image contrast. In conclusion, off-resonance proton T1rho dispersion imaging shows promise as a safe, sensitive technique for generating 17O-based T1rho contrast without exceeding SAR limitations.

References

Oct 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J PekarA C McLaughlin
Nov 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K K KwongR G Barr
Sep 16, 1991·Biochemical and Biophysical Research Communications·T AraiT Inubushi
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J GradR G Bryant
Apr 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S D Wolff, R S Balaban
Oct 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G E SantyrM J Bronskill
Jun 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A L HopkinsC B Bratton
Apr 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A L Hopkins, R G Barr
Nov 1, 1985·Journal of Computer Assisted Tomography·R E SepponenJ I Tanttu
Mar 26, 1971·Nature·S J Edelstein
Apr 14, 1971·Nature: New Biology·C S Irving, A Lapidot
Jul 1, 1981·Medical Physics·P A Bottomley, W A Edelstein
Sep 1, 1995·Journal of Magnetic Resonance. Series B·R ReddyJ S Leigh
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J PekarA C McLaughlin
Dec 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I Ronen, G Navon
Oct 1, 1994·Annals of Neurology·K A Hossmann
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G E SantyrJ A Sorenson
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W T DixonR I Pettigrew
Jan 1, 1996·Magnetic Resonance Imaging·R ReddyJ S Leigh

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Citations

May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M F LythgoeI Gordon
Oct 24, 1998·Journal of Magnetic Resonance Imaging : JMRI·R R RiziJ S Leigh
May 24, 2003·Journal of Magnetic Resonance·Sridhar R CharagundlaRavinder Reddy
Oct 1, 2010·Topics in Magnetic Resonance Imaging : TMRI·Arijitt Borthakur, Ravinder Reddy
Nov 3, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dmitry KurzhunovMichael Bock
Nov 1, 2006·NMR in Biomedicine·Arijitt BorthakurRavinder Reddy
Mar 17, 2005·NMR in Biomedicine·Xiao-Hong ZhuWei Chen
Jul 17, 2010·Progress in Nuclear Magnetic Resonance Spectroscopy·Ioannis P Gerothanassis

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