Offspring birth weight and cardiovascular risk in parents: a population-based HUNT 2 study.

American Journal of Epidemiology
Kirsti MyklestadPål R Romundstad

Abstract

Low birth weight is associated with increased risk of cardiovascular disease and type 2 diabetes in later life. The fetal insulin hypothesis suggests that shared genetic factors partly explain this association. If fetal genes predispose to both low birth weight and cardiovascular disease in adulthood, fathers of offspring with low birth weight should display an unfavorable profile of cardiovascular risk factors. To study this, the authors linked data on more than 14,000 parents, collected from the second Health Study of Nord Trøndelag County, Norway (HUNT 2, 1995-1997), to offspring data from the Norwegian Medical Birth Registry (1967-2005). Linear regression was used to study associations of offspring birth weight for gestational age with the parents' body mass index, waist circumference, blood pressure, glucose, and serum lipids. All analyses were adjusted for shared environment by means of the socioeconomic measures, lifestyle, and cardiovascular risk factors of the partner. The authors found that low offspring birth weight for gestational age was associated with increased paternal blood pressure, body mass index, waist circumference, and unfavorable levels of glucose and lipids. For mothers, associations similar to those fo...Continue Reading

References

Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Oct 16, 1986·The New England Journal of Medicine·L TallarigoR Navalesi
Jun 17, 2000·Acta Obstetricia Et Gynecologica Scandinavica·R SkjaervenL S Bakketeig
Aug 4, 2001·Scandinavian Journal of Public Health·B Backe
Jan 4, 2003·BMJ : British Medical Journal·Elina HyppönenChris Power
Aug 12, 2003·European Journal of Epidemiology·A HubinetteP Lichtenstein
Jan 20, 2004·Journal of Epidemiology and Community Health·G Davey SmithF Rasmussen
Mar 12, 2004·Seminars in Neonatology : SN·Claire Levy-MarchalPaul Czernichow
Sep 29, 2004·Pediatric Diabetes·Claire Levy-Marchal, Delphine Jaquet
Jun 14, 2005·Epidemiology·George Davey SmithFinn Rasmussen
Sep 24, 2005·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Practice Bulletins--Obstetrics
Sep 6, 2006·Diabetologia·B KnightA T Hattersley
May 9, 2007·American Journal of Epidemiology·George Davey SmithDebbie A Lawlor
Nov 6, 2007·American Journal of Epidemiology·Pål R RomundstadLars J Vatten
Dec 1, 2007·American Journal of Epidemiology·Allen J WilcoxRolv Terje Lie
Mar 25, 2008·Pediatric Research·Sandra W K De KortAnita C S Hokken-Koelega
Dec 26, 2008·JAMA : the Journal of the American Medical Association·Peter H WhincupDonald E Yarbrough
Feb 21, 2009·Diabetes·Rachel M FreathyAndrew T Hattersley
Nov 12, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Apr 8, 2010·Nature Genetics·Rachel M FreathyMark I McCarthy

❮ Previous
Next ❯

Citations

Oct 12, 2012·Current Hypertension Reports·Vidar O EdvardssonRunolfur Palsson
Nov 20, 2012·Current Opinion in Lipidology·Silvio Zaina, Gertrud Lund
Dec 18, 2013·International Journal of Epidemiology·Jessica S TyrrellTimothy M Frayling
May 30, 2014·Journal of Assisted Reproduction and Genetics·UNKNOWN ESHRE Capri Workshop Group
Feb 13, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Fredrikke Nohr MothBjørn O Åsvold
May 20, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Cesare CuspidiGuido Grassi
Mar 21, 2017·Nephron·UNKNOWN Low Birth Weight and Nephron Number Working Group
Mar 1, 2019·Journal of Developmental Origins of Health and Disease·J G B DerraikUNKNOWN SCOPE consortium
Mar 12, 2021·Journal of Developmental Origins of Health and Disease·Fareeha ShaikhØyvind Næss

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.