Ofloxacin-associated retinopathy in rabbits: role of oxidative stress

Human & Experimental Toxicology
S RampalN Sood

Abstract

Ofloxacin, a quinolone, is an extensively used, well-tolerated antibacterial agent but has been reported to induce photosensitivity at low incidences. In the present investigation, the possible role of oxidative stress in ofloxacin-induced retinopathy in rabbits was evaluated. It was observed that ofloxacin at a dose rate of 10 and 20 mg/rabbit, twice daily for 21 consecutive days, resulted in significant elevation in the extent of lipid peroxidation and depletion of the blood glutathione levels. Marked alterations were also observed in various parameters of the glutathione-redox cycle. There was significant increase in the enzymic activity of glutathione peroxidase and glutathione reductase, whereas a significant decrease was observed in the activities of superoxide dismutase, catalase, and glutathione-S-transferase enzymes. Histopathological studies revealed retinal damage especially in the pigmented cell layer. Degenerative changes in liver and kidneys were also observed. Liver showed focal areas of necrosis, dilation of sinusoids, and cellular infiltration, whereas in kidneys, there was glomerular and tubular degeneration, suggesting impaired renal functioning.

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Citations

Aug 21, 2013·Pharmacological Reports : PR·Artur BeberokEwa Buszman
Apr 24, 2014·Pharmacoepidemiology and Drug Safety·Kian EftekhariBrian L VanderBeek
Sep 12, 2015·Environmental Toxicology and Pharmacology·Anna SpodniewskaAleksandra Giżejewska
Apr 17, 2016·Chemico-biological Interactions·Soya RungsungSimrat Pal Singh Saini
Aug 30, 2011·European Journal of Pharmacology·Artur BeberokJanina Trzcionka
Mar 3, 2015·Journal of Photochemistry and Photobiology. B, Biology·Anna ZgadzajGrzegorz Nałęcz-Jawecki
Jan 14, 2018·Environmental Science and Pollution Research International·Adil Mehraj KhanNaresh Kumar Sood
Feb 21, 2019·Drug and Chemical Toxicology·Ayman Samir Farid, Ahmed Medhat Hegazy
Aug 4, 2016·Polish Journal of Veterinary Sciences·A Spodniewska, D Barski
May 12, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Xinyu YuXiang Wei

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