PMID: 9416384Jan 7, 1998Paper

Ofloxacin-induced seizure

The Annals of Pharmacotherapy
G D WaltonT G Mulpur

Abstract

To describe a possible case of ofloxacin-induced generalized tonic-clonic seizure. Although the etiology is unknown, ofloxacin most likely precipitated this patient's seizure threshold because of sepsis or secondary to drug accumulation due to the patient's compromised renal function. A 69-year-old white woman with non-small-cell lung cancer and a history of central nervous system metastatic disease treated with radiation therapy presented to the emergency department with symptoms of urosepsis. Because of multiple drug allergies she was started on ofloxacin (hospital formulary quinolone). After 4 days of therapy she developed a generalized tonic-clonic seizure. A computed tomography scan of the head with and without contrast was negative. The ofloxacin was discontinued and aztreonam therapy was started. Phenytoin therapy was instituted and, despite serum concentrations below the conventional therapeutic range, there was no recurrence of seizure. Subsequent discontinuation of phenytoin did not result in a seizure for this patient. Seizures induced by the fluoroquinolones are uncommon. The histopathologic features of this phenomenon are currently unknown. In this patient, imaging studies were negative for structural defects, ruli...Continue Reading

References

May 1, 1992·The Annals of Pharmacotherapy·M B O'ConnellS D Bannick-Mohrland
Feb 1, 1988·Annals of Internal Medicine·J S Wolfson, D C Hooper
Aug 1, 1987·Annals of Internal Medicine·A SaxonD C Adelman
Oct 1, 1973·Annals of Internal Medicine·R W Jelliffe
Nov 1, 1984·The Journal of Infectious Diseases·R N GreenbergA A Noorani
Jan 1, 1982·The Medical Clinics of North America·A R Mayrer, V T Andriole
Feb 1, 1982·British Journal of Clinical Pharmacology·U BustoE M Sellers
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Jul 1, 1993·Antimicrobial Agents and Chemotherapy·A De SarroG B De Sarro
Mar 1, 1993·Neurology·A B Ettinger, S Shinnar
Dec 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S M TraegerN A Nackes

❮ Previous
Next ❯

Citations

May 11, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Bart PostMarina A J Tijssen
May 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Catherine Cone, Bruce Horowitz
Sep 12, 2000·The Annals of Pharmacotherapy·S Melvani, B R Speed
May 12, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S J MartinC G Garvin
Oct 26, 2001·The Annals of Pharmacotherapy·J M KushnerC R Snyder
Jun 27, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S F KoussaM A Riachi
Jan 27, 2004·The Annals of Pharmacotherapy·Carrie A Quigley, Janet R Lederman
Feb 14, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Geetha Ramachandran, Soumya Swaminathan
Sep 28, 2001·The Annals of Pharmacotherapy·J A Paladino
Feb 11, 2010·Case Reports in Medicine·Pierre LahmekHenri-Jean Aubin
May 19, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ana M Tomé, Augusto Filipe
Dec 20, 2007·The Journal of ECT·Irving M Reti, Dimitry S Davydow
Jul 28, 2010·CNS Drugs·Joseph S Kass, Wayne X Shandera

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

MedGenMed : Medscape General Medicine
Sonal SinghSundar Venkatesh
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Mingyue WangBo Xiao
© 2021 Meta ULC. All rights reserved