Ofloxacin susceptibility testing quality control parameters for microdilution and disk diffusion, and confirmation of disk diffusion interpretive criteria.

Journal of Clinical Microbiology
P C FuchsT L Gavan

Abstract

The susceptibilities of 221 clinical isolates to ofloxacin were tested simultaneously by broth microdilution and disk diffusion methods with commercially prepared 5-micrograms ofloxacin disks. The acceptability of the following previously proposed zone diameter breakpoints was confirmed: greater than or equal to 16 mm, susceptible; 13 to 15 mm, intermediate; less than or equal to 12 mm, resistant. On the basis of a multilaboratory collaborative study, the following are proposed as acceptable ofloxacin MIC ranges for quality control organisms: Escherichia coli ATCC 25922, 0.03 to 0.06 micrograms/ml; Staphylococcus aureus ATCC 29213, 0.12 to 0.5 micrograms/ml; Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 29212, 1.0 to 4.0 micrograms/ml. Ofloxacin quality control zone diameter ranges for the disk diffusion test are tentatively proposed, but variations in the performance of different lots of Mueller-Hinton agar may prove to be a serious problem for users.

References

Oct 1, 1985·Antimicrobial Agents and Chemotherapy·J S Wolfson, D C Hooper
Sep 1, 1987·Antimicrobial Agents and Chemotherapy·H LodeP Koeppe
Aug 1, 1985·Journal of Clinical Microbiology·P C FuchsC Thornsberry
Nov 1, 1985·Journal of Clinical Microbiology·W Mandell, H C Neu
Dec 1, 1984·The Journal of Antimicrobial Chemotherapy·M R LockleyJ Dent
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·K SatoS Mitsuhashi

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Citations

Oct 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A BarryL Reller
Dec 1, 1989·Journal of Clinical Microbiology·A L Barry, R N Jones
Oct 1, 1989·Clinical Microbiology Reviews·J S Wolfson, D C Hooper
Jul 1, 1993·Journal of Clinical Microbiology·M A PfallerP C Fuchs

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