May 28, 2020

Often Only a Side Event, but Sometimes Groundbreaking - an Ectopic ACTH Secretion as an Example of a Paraneoplastic Syndrome

Praxis
Christoph HerdaCristian Camartin

Abstract

Often Only a Side Event, but Sometimes Groundbreaking - an Ectopic ACTH Secretion as an Example of a Paraneoplastic Syndrome Abstract. Various tumors can cause a paraneoplastic ACTH production, particularly small-cell lung cancers. Patients suffer from a secondary Cushing syndrome with hypokalemia, hypertension, hyperglycemia and edema. There are three therapeutic approaches: treatment of the underlying disease, hormonal inhibition and symptomatic treatment. The prognosis of an ACTH-producing lung cancer is poor due to numerous complications. In the presented case study, the patient refused treatment of the underlying disease, therefore a palliative symptomatic treatment became of great importance.

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Mentioned in this Paper

Cell Secretion
POMC
Hypertensive Disease
Edema
Paraneoplastic Syndromes
Small Cell Carcinoma of Lung
Neoplasms
Corticotropin
Ectopic (Qualifier Value)
Hyperglycemia

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