OGG1 polymorphisms and breast cancer risk.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Pavel RossnerRegina M Santella

Abstract

The role of oxidative stress in breast cancer risk is still unclear. OGG1 encodes an 8-oxoguanine DNA glycosylase/AP lyase that catalyzes the removal of 8-oxodeoxyguanosine from DNA. 8-Oxodeoxyguanosine, the most abundant lesion generated by oxidative stress, is highly mutagenic. Environmental sources of oxidative stress, such as alcohol consumption, cigarette smoking, high body mass index (BMI), and low fruits and vegetables intake, may modify the association of genetic polymorphisms with breast cancer risk. We investigated the association between three genetic polymorphisms in OGG1 (Ser(326)Cys, 7143A/G, and 11657A/G) and breast cancer risk among 1,058 cases and 1,102 controls participating in the Long Island Breast Cancer Study Project. No associations were observed between individual OGG1 polymorphisms, haplotypes, or diplotypes and breast cancer. The association between having at least one variant allele and breast cancer risk was stronger among moderate alcohol drinkers for Ser(326)Cys [odds ratio (OR), 1.82; 95% confidence interval (95% CI), 1.06-3.10] relative to nondrinkers with the wild-type genotype and among those with higher BMI for 7143A/G (OR, 1.47; 95% CI, 1.10-1.96) and for 11657A/G (OR, 1.41; 95% CI, 1.05-1.88...Continue Reading

References

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Dec 14, 2005·Carcinogenesis·Mary Beth TerryRegina M Santella

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Citations

Oct 9, 2007·Breast Cancer Research and Treatment·Suleeporn SangrajrangOdilia Popanda
Jan 9, 2010·Breast Cancer Research and Treatment·Weiguang YuanDianjun Li
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Hans-Peter RihsThomas Bruning
Nov 25, 2014·BMC Cancer·Patricia RodriguesPilar Eroles
Mar 4, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marilie D Gammon, Regina M Santella
Apr 16, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ching-Yu YenHsueh-Wei Chang
Apr 6, 2011·Molecular Carcinogenesis·Minkyo SongDaehee Kang
Mar 8, 2016·International Journal of Cancer. Journal International Du Cancer·Irina MordukhovichMarilie D Gammon
Feb 2, 2013·The Breast : Official Journal of the European Society of Mastology·Hui XieXiaoxiang Chen
Nov 9, 2016·Pathology Oncology Research : POR·Mohammed AlanaziNarasimha Reddy Parine
Jun 14, 2017·The Breast Journal·Ali Sanjari MoghaddamAlireza Mosavi Jarrahi
Dec 15, 2010·Breast Cancer Research and Treatment·Xiaoxiang ChenYaping Wang
Mar 30, 2016·World Journal of Gastroenterology : WJG·Ching-Yu LaiChih-Ching Yeh
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Maosheng HuangXifeng Wu
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Haixin LiKexin Chen

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