Oil and drug control the release rate from lyotropic liquid crystals

Journal of Controlled Release : Official Journal of the Controlled Release Society
Isabelle MartielRaffaele Mezzenga

Abstract

The control of the diffusion coefficient by the dimensionality d of the structure appears as a most promising lever to efficiently tune the release rate from lyotropic liquid crystalline (LLC) phases and dispersed particles towards sustained, controlled and targeted release. By using phosphatidylcholine (PC)- and monolinoleine (MLO)-based mesophases with various apolar structural modifiers and water-soluble drugs, we present a comprehensive study of the dimensional structural control of hydrophilic drug release, including 3-d bicontinuous cubic, 2-d lamellar, 1-d hexagonal and 0-d micellar cubic phases in excess water. We investigate how the surfactant, the oil properties and the drug hydrophilicity mitigate or even cancel the effect of structure variation on the drug release rate. Unexpectedly, the observed behavior cannot be fully explained by the thermodynamic partition of the drug into the lipid matrix, which points out to previously overlooked kinetic effects. We therefore interpret our results by discussing the mechanism of structural control of the diffusion rate in terms of drug permeation through the lipid membrane, which includes exchange kinetics. A wide range of implications follow regarding formulation and future d...Continue Reading

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Citations

Dec 27, 2015·Colloids and Surfaces. B, Biointerfaces·Lorena TavanoRita Muzzalupo
Dec 15, 2015·Therapeutic Delivery·Intan D M AzmiAnan Yaghmur
Sep 4, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Angela ChemelliOtto Glatter
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Jul 27, 2021·Journal of Colloid and Interface Science·Younus MohammadShakila B Rizwan
Apr 2, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Reza GhanbariRaffaele Mezzenga
Jun 11, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Kim MishraErich J Windhab
Jul 14, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Jijo J VallooranEhud M Landau

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