PMID: 2506933Sep 4, 1989Paper

Okadaic acid and dinophysistoxin-1, non-TPA-type tumor promoters, stimulate prostaglandin E2 production in rat peritoneal macrophages

Biochimica Et Biophysica Acta
K OhuchiH Fujiki

Abstract

Okadaic acid and dinophysistoxin-1 isolated from a black sponge, Halichondria okadai are non-12-O-tetrade-canoylphorbol 13-acetate (non-TPA)-type tumor promoters of mouse skin. Okadaic acid at concentrations of 10-100 ng/ml stimulated prostaglandin E2 production in rat peritoneal macrophages. Dinophysistoxin-1 (35-methylokadaic acid) stimulated prostaglandin E2 production as strong as okadaic acid, but okadaic acid tetramethyl ether, an inactive compound as a tumor promoter, did not. Okadaic acid at 10 ng/ml (12.4 nM) stimulated prostaglandin E2 production as strongly as TPA at 10 ng/ml (16.2 nM) 20 h after incubation. Unlike TPA-type tumor promoters, okadaic acid required a lag phase before stimulation. The duration of this lag phase was dependent on the concentration of okadaic acid. Indomethacin inhibited okadaic acid-induced preostaglandin E2 production in a dose-dependent manner, and its inhibition was more strongly observed in okadaic acid-induced prostaglandin E2 production. Cycloheximide inhibited okadaic acid-induced release of radioactivity from [3H]arachidonic acid-labeled macrophages and prostaglandin E2 production dose dependently, suggesting that protein synthesis is a prerequisite for the stimulation of arachidon...Continue Reading

References

Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SuganumaT Sugimura
Oct 1, 1988·Japanese Journal of Cancer Research : Gann·H FujikiT Yasumoto
Jun 19, 2008·Cancer Research·Jennifer S CarewJohn L Cleveland

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Citations

Aug 1, 1996·Pflügers Archiv : European journal of physiology·S LloretJ J Moreno
Apr 1, 1993·European Journal of Biochemistry·M MachidaT Tanaka
Jun 14, 2008·Journal of Leukocyte Biology·Dawn E TuckerChristina C Leslie
Jan 1, 1992·Japanese Journal of Cancer Research : Gann·T OikawaM Shimamura
Dec 17, 2008·The Journal of Organic Chemistry·Timothy M TrygstadCraig J Forsyth
Nov 12, 1990·Biochimica Et Biophysica Acta·M WatanabeK Ohuchi
Mar 1, 1990·Trends in Biochemical Sciences·P CohenY Tsukitani

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