Olanzapine for chemotherapy-induced nausea and vomiting: systematic review and meta-analysis

Pharmacy Practice
Legese ChelkebaTsegaye Melaku

Abstract

Chemotherapy induced nausea and vomiting (CINV) remains the most distressing event in patients receiving highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC). Therefore, this meta-analysis was conducted to evaluate the efficacy of olanzapine containing regimen in preventing acute, delayed and overall phases of CINV. PubMed, EBSCO, and Cochrane central register of controlled trials electronic databases were searched to identify RCTs that compared the effects of olanzapine with non-olanzapine regimen in preventing CINV. Randomized clinical trials (RCTs) that compared olanzapine containing regimen with non-olanzapine regimen were included. The primary outcomes were the percentage of patients achieving no vomiting or no nausea in acute, delayed and overall phases. 13 RCTs that enrolled 1686 participants were included in this meta-analysis. 852 patients were assigned to olanzapine and 834 patients were assigned to non-olanzapine regimen (other standard antiemetic regimen). The percentages of no emesis achieved were 87.5%, 76.2%, 73.6% in olanzapine versus 76.7%, 61.8%, and 56.4% in non-olanzapine regimen in acute, delayed and overall phases, respectively. The percentages of no nausea were 82%, 64.3%, 61.6...Continue Reading

Citations

Sep 25, 2018·The Cochrane Database of Systematic Reviews·Anna SutherlandBee Wee
Mar 28, 2018·The Journal of Pharmacology and Experimental Therapeutics·Natasha D BushDavid C Wright
Dec 14, 2019·Neuro-oncology Practice·Vijay M PatilRakesh Jalali
Jan 8, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ronald ChowRudolph M Navari

❮ Previous
Next ❯

Software Mentioned

Rev Man

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Suthan ChanthawongAumkhae Sookprasert
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Rudolph M NavariCynthia S Johnson
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Brigitte Bloechl-DaumJørn Herrstedt
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Leonard ChiuCarlo DeAngelis
© 2022 Meta ULC. All rights reserved