Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus

Neurochemistry International
Takahira YamauchiAkio Wanaka

Abstract

Weight gain is increasingly recognized as an unwanted side effect of atypical antipsychotic drugs. To explore the mechanisms underlying this side effect, we examined the effects of olanzapine, an atypical antipsychotic drug, on cellular proliferation and differentiation in the adult mouse hypothalamus. A 6-week treatment with olanzapine resulted in a significant increase in body weight. The sizes and numbers of olanzapine-treated mouse adipocytes were significantly larger than those of control mice. No significant differences were observed in the levels of blood insulin, cholesterol, triglyceride, leptin, and ghrelin among olanzapine-, haloperidol-treated and control mice with an exception that adiponectin was significantly higher in olanzapine group than control group. Body temperature and the level of uncoupling protein 2 were also comparable between the olanzapine-treated and control groups. We found that the treatment increased BrdU-incorporating cell numbers in the hypothalamus, while the same regimen with haloperidol or control had little effect on cellular proliferation. Double-labeling immunohistochemistry revealed that the majority of the BrdU-positive cells were also Olig2- or APC-positive, indicating that oligodendro...Continue Reading

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Citations

Aug 16, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sohei KimotoToshifumi Kishimoto
Aug 21, 2013·Psychoneuroendocrinology·Qingsheng ZhangXu-Feng Huang
Nov 21, 2012·The International Journal of Neuropsychopharmacology·Yuan RenLan Xiao
Jul 5, 2011·Expert Review of Neurotherapeutics·Mark WalterfangChristos Pantelis
Mar 25, 2018·European Archives of Psychiatry and Clinical Neuroscience·Natalya S Kolomeets, Natalya A Uranova

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