Olanzapine solvates

Journal of Pharmaceutical Sciences
Cristina CavallariAdamo Fini

Abstract

Olanzapine was crystallized from 12 organic solvents alone or in mixture, by cooling in the freezer, by slow evaporation of the solvent, or by suspending olanzapine powder for some time in the solvent. All the samples thus obtained were examined by thermal analysis (differential scanning calorimetry-DSC and thermogravimetry-TG) to certify the formation of a solvate, the presence of polymorph (form 1 or 2) in the desolvated olanzapine, comparing the different profile of the thermograms, and to calculate the stoichiometry of the possible solvate. According to the DSC thermogram, the solvents can be divided into four classes: those that do not form solvates and leave olanzapine form 1 (ethyl acetate, toluene, diethyl ether, and acetone); those that form solvate and leave form 1 of olanzapine after desolvation (methanol, 1- and 2-propanol); those that after desolvation of the solvate show a polymorph transition in the thermogram indicating the presence of form 2 of olanzapine (ethanol); other solvents (tetrahydrofuran, chloroform, acetonitrile) give solvate thermograms, where this last thermal trace is only poorly evident. With few exceptions, each solvent forms solvate both when pure and in mixture (10%, v/v, in ethyl acetate). Me...Continue Reading

References

Jul 26, 2005·International Journal of Pharmaceutics·Griselda I PollaGustavo Dartayet
Sep 5, 2006·International Journal of Pharmaceutics·A P AyalaD R Vega
Nov 5, 2011·Acta Crystallographica. Section C, Crystal Structure Communications·Ranjit Thakuria, Ashwini Nangia

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Citations

Apr 9, 2020·Chemical Communications : Chem Comm·Aurora J Cruz-CabezaAlessia Bacchi
Oct 6, 2017·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Kashyap Kumar SarmahRanjit Thakuria
Dec 5, 2013·Pharmaceutics·Cristina CavallariGiancarlo Ceschel
Sep 5, 2021·International Journal of Pharmaceutics·Weizhong GongSohrab Rohani

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