PMID: 16531716Mar 15, 2006Paper

Olanzapine use in cancer patients for refractory vomiting

Gan to kagaku ryoho. Cancer & chemotherapy
Takuya Shinjo, Masakuni Okada

Abstract

Recent investigations suggest the efficacy of olanzapine in cancer patients with intractable vomiting or chemotherapy-induced nausea. Olanzapine,indicated for schizophrenia in Japan, has an affinity for multiple neurotransmitter receptors including dopaminergic, serotonergic, histaminergic, adrenergic and muscarinic receptors. This pharmacological activity thus has a potential role in the treatment of nausea and vomiting. In the present study, olanzapine was given to five cancer patients with refractory vomiting to standard medications. In 3 cases, olanzapine resolved vomiting completely and also improved anorexia, In 2 cases, vomiting was controlled for a limited period. No adverse effect was observed. These results suggest olanzapine is a useful agent for the management of both vomiting and anorexia.

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Citations

Nov 7, 2020·International Journal of Molecular Sciences·Rahul PatelAmr ElShaer

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