PMID: 8935812Mar 1, 1996

Olanzapine versus placebo: results of a double-blind, fixed-dose olanzapine trial

Psychopharmacology
C BeasleyS H Hamilton

Abstract

Olanzapine is a potential new "atypical" antipsychotic agent. This double-blind, acute phase study compared two doses of olanzapine [1 mg/day (Olz1.0); 10 mg/day (Olz10.0)] with placebo in the treatment of 152 patients who met the DSM-III-R criteria for schizophrenia and had a Brief Psychiatric Rating Scale (BPRS)-total score (items scored 0-6) > or = 24. In overall symptomatology improvement [BPRS-total score and Positive and Negative Syndrome Scale (PANSS)-total score], Olz10.0 was statistically significantly superior to placebo. In positive symptom improvement (PANSS-positive score, BPRS-positive score), Olz10.0 was statistically significantly superior to placebo. In negative symptom improvement (PANSS-negative score), Olz10.0 was statistically superior to placebo. Olz 1.0 was clinically comparable to placebo in all efficacy comparisons. The only adverse event to show an overall statistically significant incidence difference was anorexia (reported for 10% of placebo-treated and 0% of Olz10.0-treated patients). The Olz10.0-treated patients improved over baseline with respect to parkinsonian and akathisia symptoms, and these changes were comparable with those observed with placebo. There were no dystonias associated with Olz10...Continue Reading

References

May 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·T R Barnes
Jan 1, 1989·Psychopharmacology·D E Casey
Oct 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·A K Gopalaswamy, R Morgan
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frank P BymasterD T Wong
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E Stockton, K Rasmussen
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C BeasleyS H Hamilton

Citations

May 1, 1997·Journal of Clinical Pharmacology·Peter F Buckley
Feb 12, 2008·Social Psychiatry and Psychiatric Epidemiology·Michael LindenHans-Peter Hundemer
Feb 26, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Stefan LeuchtRolf R Engel
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Frank P BymasterDavid L Mckinzie
Aug 14, 2003·Biological Psychiatry·Steven G PotkinInterSePT Study Group
Dec 19, 1996·European Journal of Pharmacology·S KongsamutA Sandrasagra
Feb 13, 2001·Journal of Psychiatric Research·T PollmächerD Hinze-Selch
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Albert Hung Choy Wong, Hubert H M Van Tol
Apr 15, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Julio BobesMiguel Gutiérrez
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·José Manuel MontesEFESO Study Group
Jan 13, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·H RosengartenA J Friedhoff
Mar 31, 1999·Journal of Pain and Symptom Management·S D Passik, M Cooper
Oct 25, 2001·Journal of Clinical Epidemiology·José Antonio SacristánP Kind
Apr 22, 2004·Schizophrenia Research·J P LindenmayerVirginia Stauffer
Feb 19, 1998·Schizophrenia Research·J L WaddingtonE O'Callaghan
Apr 6, 1999·Schizophrenia Research·R G Petty
Apr 6, 1999·Schizophrenia Research·R A Dickson, W M Glazer
Dec 11, 1999·Schizophrenia Research·K TuiskuR Rimon
Oct 14, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·P CarrièreT Lempérière
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M M MarcusT H Svensson
Oct 6, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S KasperA Heiden
Dec 14, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Enrique AlvarezEUROPA Study Group
May 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C BeasleyJ N Beuzen
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jue HeXin-Min Li
Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Abegale W HartfieldPeter G Clifton
Sep 28, 1999·Clinical and Experimental Pharmacology & Physiology·S SchenkerM Lee
Mar 11, 1999·The New England Journal of Medicine·Parkinson Study Group
Dec 4, 2003·Journal of Child and Adolescent Psychopharmacology·Tamar MozesRoberto Mester
Mar 1, 2012·Journal of Child and Adolescent Psychopharmacology·Ludmila KryzhanovskayaOlawale Osuntokun
Jan 11, 2008·Schizophrenia Bulletin·Robert P McMahonWilliam T Carpenter
Aug 15, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·R P MaloneM A Delaney
Jan 25, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Robert L FindlingS Charles Schulz
Mar 17, 2001·International Clinical Psychopharmacology·John M Kane
Jul 19, 2001·International Clinical Psychopharmacology·S KasperRODOS Investigator Group
Mar 11, 2004·Psychiatry and Clinical Neurosciences·Won-Myong BahkKwang-Soo Kim
Jun 27, 2000·Australian and New Zealand Journal of Medicine·A S Granger, H C Hanger
Aug 2, 2013·BMC Pharmacology & Toxicology·Elizabeth BrunnerChetan Chinmaya Shatapathy
May 11, 2011·PloS One·Toshi A Furukawa, Stefan Leucht
Jul 23, 1999·Pharmacotherapy·Y C ChanG Neufeld
Jan 5, 2002·CNS Drugs·Daniel TarsyFrank I Tarazi
Feb 5, 2014·Schizophrenia Bulletin·Stefan LeuchtJohn M Davis
Nov 23, 2013·Schizophrenia Research·Myrto T SamaraStefan Leucht
Jun 28, 2014·Vascular Pharmacology·Joanne Y T LeungAlasdair M Barr
Aug 3, 2007·Journal of Automated Methods & Management in Chemistry·Faten A Nour El-DienAhmed G El-Nahas
Jan 5, 2002·Journal of Clinical Psychopharmacology·F E ScheepersR S Kahn
Dec 31, 1997·Journal of Clinical Psychopharmacology·P J PerryC Beasley
Feb 13, 2001·Biological Psychiatry·G D TollefsonLilly Resistant Schizophrenia Study Group
Jan 1, 1997·International Journal of Psychiatry in Clinical Practice·P Meats
Jul 14, 2005·Expert Opinion on Drug Safety·Paul J Goodnick
Jul 24, 2013·Expert Opinion on Drug Safety·Charles Schulz, Robert J Haight
Sep 13, 2013·Expert Opinion on Drug Safety·Daniel SchöttleDieter Naber
Jul 2, 2005·Expert Opinion on Investigational Drugs·C A Tamminga, John M Kane
Oct 29, 2008·Current Medical Research and Opinion·Natalie C EdwardsRiad Dirani
Jun 20, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hubert H FernandezJoseph H Friedman
Nov 24, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Paz TorenAbraham Weizman
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·N GhaemiF K Goodwin
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·H J Möller
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·H J Möller
Jan 8, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Maria Isaac, Armin Koch
Dec 6, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Ludmila KryzhanovskayaM Tohen
Jul 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Romain BeitingerStefan Leucht
Mar 12, 2008·Regulatory Toxicology and Pharmacology : RTP·Joel P BercuRoger D Meyerhoff
Apr 21, 2007·Psychiatry Research·Marc De HertJozef Peuskens
Dec 3, 2005·Child and Adolescent Psychiatric Clinics of North America·Harvey N KranzlerSanjiv Kumra
Apr 12, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco AngelucciAleksander A Mathé
Nov 25, 2004·Schizophrenia Research·John LaurielloRobert A Lasser
Oct 12, 2004·Schizophrenia Research·Dawn I VelliganM Lynn Crismon
Aug 26, 2006·Schizophrenia Research·Brendan P MurphyPatrick D McGorry
Jun 30, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yue HouTao Guo
Apr 8, 2006·Eating Behaviors·Paolo ScoccoFederico Caon
Apr 10, 2003·The Psychiatric Clinics of North America·Robin Emsley, Piet Oosthuizen
Mar 16, 2001·Expert Opinion on Pharmacotherapy·B C Lund, P J Perry
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S Kasper, F Müller-Spahn
Jul 28, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alkomiet HasanWorld Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Treatment Guidelines for Schizophrenia
Mar 21, 2015·Schizophrenia Research·Stephen Z LevineStefan Leucht
Jun 23, 2012·Neuropharmacology·Bruce J Kinon, Juan-Carlos Gómez
Feb 9, 2006·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·S L TunisR A Browne
Aug 27, 2013·European Journal of Pharmacology·Megumi IkegamiJunzo Kamei
Oct 26, 2005·International Journal of Psychiatry in Medicine·Francisca Llinares TelloJuan Pablo Ordovás Baines
Apr 6, 1999·Schizophrenia Research·D E Casey
Sep 1, 1999·Acta Neuropsychiatrica·M J Hoes
Nov 5, 2002·Schizophrenia Research·Herbert Y MeltzerKaruna Jayathilake
Jan 12, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·M C MauriF Barale
Nov 1, 2002·Schizophrenia Research·Julie A KreyenbuhlRobert R Conley
Oct 6, 2005·Journal of Psychopharmacology·Peter J Weiden
Sep 22, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Peter FalkaiWFSBP Task Force on Treatment Guidelines for Schizophrenia
Jan 24, 2002·The Journal of International Medical Research·T Burns, R Bale
Sep 11, 2004·Journal of Psychopharmacology·Robert R ConleyCharles M Richardson
Sep 18, 2015·Journal of Geriatric Psychiatry and Neurology·Massimiliano BuoliAlfredo Carlo Altamura
Oct 31, 2002·Human Psychopharmacology·Matteo BalestrieriCesario Bellantuono
Oct 19, 2006·Journal of Psychopharmacology·Simon Burton
Apr 23, 2005·The Cochrane Database of Systematic Reviews·L DugganS Indran
Oct 11, 2001·Journal of Clinical Psychopharmacology·Q Cordeiro, H Elkis
May 17, 2006·Journal of Clinical Psychopharmacology·Michael LindenJoerg Czekalla
Jun 20, 2006·Human Psychopharmacology·Pinkhas SirotaEleonora Tchernichovsky
Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefan LeuchtRolf R Engel
Jan 24, 2007·Journal of Psychiatric Practice·Peter J Weiden
Dec 11, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Christine D Esper, Stewart A Factor
Nov 18, 2008·Journal of Clinical Psychopharmacology·Bruce J KinonJennifer Sniadecki
Jun 13, 2003·The Journal of Head Trauma Rehabilitation·Elie Paul ElovicJoseph H Ricker
May 28, 2005·The Journal of Nervous and Mental Disease·Steven L SayersStanley N Caroff
Nov 17, 2009·Journal of Clinical Psychopharmacology·Ira D GlickCarla M Canuso
Nov 12, 2005·Journal of Clinical Psychopharmacology·Ulrike WeissWolfgang Aichhorn
Feb 24, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T Wetterling
Oct 22, 2010·Psychological Medicine·T R MarquesS Kapur
Nov 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·P V TranC Beasley
Mar 31, 1998·The British Journal of Psychiatry : the Journal of Mental Science·C S Thomas, S Lewis
Dec 16, 2016·The Cochrane Database of Systematic Reviews·Ranganath D RattehalliStephanie Sampson
Dec 17, 2019·The American Journal of Psychiatry·Stefan LeuchtJohn M Davis
Apr 19, 2000·Journal of Clinical Psychopharmacology·P Mohr, P Czobor
Feb 6, 1999·Journal of Clinical Psychopharmacology·R D Sanders, D Mossman
Dec 31, 1997·Journal of Clinical Psychopharmacology·S W FlynnW G Honer
Jun 1, 2000·Journal of Clinical Psychopharmacology·B D Bronson, J P Lindenmayer
Feb 7, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·T BottaiE Perrin
Jun 17, 2011·The Cochrane Database of Systematic Reviews·John BolaHaluk Soydan
Apr 8, 2020·Frontiers in Psychiatry·Carol KanHubertus Himmerich
Sep 13, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hoda MoteshafiEmmanuel Stip
Apr 1, 1997·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·C A Tamminga
May 4, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·O Blin
Sep 1, 1998·Acta Neuropsychiatrica·J À CampoH Merckelbach
Jun 28, 2000·Biopharmaceutics & Drug Disposition·M AravagiriS R Marder
May 9, 2012·Journal of Clinical Psychopharmacology·Bruce J KinonHong Liu-Seifert
Dec 10, 1997·The Annals of Pharmacotherapy·J C KandoA I Green
Aug 10, 1999·Journal of Clinical Psychopharmacology·T Wetterling, H E Müssigbrodt
Mar 12, 1999·British Journal of Clinical Pharmacology·M CampbellS H Thomas
Feb 17, 2000·The Annals of Pharmacotherapy·P S Masand, S L Berry

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