Old and new serological tests for celiac disease screening

Expert Review of Gastroenterology & Hepatology
Umberto VoltaErica Fiorini

Abstract

Evaluation of: Lewis NR, Scott BB. Meta-analysis: deamidated gliadin peptide (DGP) antibody and tissue transglutaminase (tTG) antibody compared as screening test for celiac disease. Aliment. Pharmacol. Ther. 31(1), 73-81 (2010). In celiac disease (CD), deamidation of gliadin peptides, induced by tissue transglutaminase (tTG), generates novel antigenic epitopes evoking a specific immune response. Serological tests based on the detection of antibodies to deamidated gliadin peptides (DGP) have been developed with very promising results in terms of sensitivity and specificity for CD screening. In the present study, a meta-analysis of studies published from 1998 to 2008 was designed to compare the performance of DGP antibodies with that of tTG antibodies, the validated and routinely employed test for CD screening. The authors have limited their analysis to IgA class antibodies underlining that most of the considered studies had methodological imperfections, especially ascertainment bias. The results of this meta-analysis indicated that the pooled sensitivities for DGP and tTG antibodies were 87.8% (95% CI: 85.6-89.9) and 93% (95% CI: 91.2-94.5), respectively, and the pooled specificities were 94.1% (95%CI: 92.5-95.5) and 96.5% (95% ...Continue Reading

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Citations

Apr 8, 2014·Digestive Diseases and Sciences·Kumar PallavDaniel A Leffler
Apr 6, 2013·Journal of Clinical Immunology·Sergio AmarriUmberto Volta
Nov 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Umberto VoltaRoberto De Giorgio
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Feb 1, 2011·Cellular & Molecular Immunology·U Volta, V Villanacci
Jul 26, 2011·Expert Review of Gastroenterology & Hepatology·Umberto VoltaGiacomo Caio
Aug 25, 2020·Current Opinion in Pediatrics·Michele J Alkalay
May 10, 2020·BMJ Open Gastroenterology·Matteo GuarinoGiacomo Caio
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Jun 25, 2021·Frontiers in Immunology·Anna TorunBeata Pyrzynska
Nov 13, 2020·Pathologica·Vincenzo VillanacciPaola Parente

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