Old and Novel Functions of Caspase-2

International Review of Cell and Molecular Biology
M A MilesC J Hawkins

Abstract

Although caspase-2 is a highly conserved protease that has received a lot of research attention, consensus about its roles and the molecular mechanisms that underpin them has been elusive. Recent improvements to our understanding of the activities of caspase-2 have been facilitated by the development and refinement of techniques allowing identification of cellular processes instigated by this caspase. Following DNA damage, caspase-2 can be activated in a molecular complex called the "PIDDosome"; however, other stimuli provoke caspase-2-dependent activities that do not appear to involve this complex. Further research is needed into the mechanisms that activate caspase-2, and the substrates that it cleaves to accomplish its functions. Apart from DNA damage, caspase-2 has also been implicated in responses to other cellular stresses including oxidative damage, endoplasmic reticulum stress, and aberrant mitotic signaling. Caspase-2 sensitized animals fed diets high in fat and sugar to glucose intolerance and liver disease, so drugs that target this protease may be useful to prevent or treat metabolic conditions. Caspase-2 loss enhanced the survival of retinal ganglion cells following optic nerve damage, prompting hope that caspase-2...Continue Reading

Citations

Aug 8, 2018·Cell Death and Differentiation·Yoon LimSharad Kumar
Jan 22, 2020·The FEBS Journal·Dana KalabovaVeronika Obsilova
May 11, 2018·Cell Death and Differentiation·Claire H Wilson, Sharad Kumar
Apr 13, 2019·Cell Death and Differentiation·Marcin PorebaMarcin Drag
Jan 30, 2021·Neural Regeneration Research·Peng Liu, Karen H Ashe
Mar 24, 2021·Trends in Cell Biology·Gelina S Kopeina, Boris Zhivotovsky
Apr 16, 2021·Experimental & Molecular Medicine·Yoon LimSharad Kumar
Dec 17, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Xianmei MengJianyuan Chai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.