Old dogs that learn new tricks: modified antimicrobial agents that escape pre-existing resistance mechanisms

International Journal of Medical Microbiology : IJMM
Stefan Schwarz, Corinna Kehrenberg

Abstract

Increasing numbers of resistant bacteria and decreasing numbers of efficient antimicrobial agents demand for the development of new highly potent antimicrobial agents. The two main directions for the development of new antimicrobial agents are either the development of completely novel antimicrobial agents, or the modification of already existing antimicrobial molecules. The second direction proved to be a more successful and cost-efficient way of generating new antimicrobial agents. For this, chemical modifications have been included which render the antimicrobial agents insensitive to prevalent bacterial resistance mechanisms. However, detailed knowledge of the resistance mechanisms is indispensable. Molecular analysis of resistance mechanisms provides the required data to identify critical target structures. Furthermore, modification of antimicrobial agents makes it possible to escape known resistance mechanisms. In this report, two examples for such successful developments, one from human medicine (telithromycin) and the other from veterinary medicine (florfenicol), are presented.

References

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Oct 5, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Franz-Josef SchmitzStefan Schwarz
Mar 5, 2003·The Journal of Antimicrobial Chemotherapy·Grit Ackermann, Arne C Rodloff
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Saskia Priebe, Stefan Schwarz
Mar 26, 2004·Nature Reviews. Microbiology·Christopher Walsh
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Nov 13, 2004·FEMS Microbiology Reviews·Stefan SchwarzAxel Cloeckaert
Apr 15, 2005·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·I PaschR Kroker

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Citations

Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·B CatryA De Kruif
Dec 24, 2011·Annals of the New York Academy of Sciences·Stefan SchwarzKristina Kadlec
Jan 28, 2015·Journal of Veterinary Pharmacology and Therapeutics·M G MaalandL Guardabassi
Mar 31, 2015·Future Microbiology·Geovana Brenner MichaelStefan Schwarz
Nov 3, 2016·Cold Spring Harbor Perspectives in Medicine·Stefan SchwarzBirte Vester

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