Old enzymes versus new herbicides

The Journal of Biological Chemistry
Tamara L Hendrickson

Abstract

The introduction of manmade chemicals, including the herbicide atrazine, into the environment has led to the emergence of microorganisms with new biodegradation pathways. Esquirol et al. demonstrate that the AtzE enzyme catalyzes a central step in atrazine degradation and that expression of AtzE requires coexpression of the small protein AtzG. Remarkably, AtzG and AtzE appear to have evolved from GatC and GatA, components of an ancient enzyme involved in indirect tRNA aminoacylation, providing an elegant demonstration of metabolic repurposing.

References

Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·A W CurnowD Söll
Apr 27, 2000·Trends in Biochemical Sciences·P Schimmel, L Ribas De Pouplana
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephane SkouloubrisTamara L Hendrickson
Jul 1, 2006·Science·Akiyoshi NakamuraIsao Tanaka
Nov 21, 2017·Current Opinion in Chemical Biology·Udumbara M RathnayakeTamara L Hendrickson
Mar 11, 2018·The Journal of Biological Chemistry·Lygie EsquirolColin Scott

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