PMID: 8943067Nov 26, 1996Paper

Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males

Proceedings of the National Academy of Sciences of the United States of America
S M PincusJ D Veldhuis

Abstract

New statistical perspectives on the secretory patterns of both luteinizing hormone (LH) and testosterone (T) may prove useful in further understanding the aging process, and possibly ultimately in improving the diagnosis and treatment of spermatogenetic failure and loss of sexual interest. We examined serum concentration time-series for LH and T in 14 young (21-34 years of age) and 11 aged (62-74 years of age) healthy men. For each subject, blood samples were obtained at 2.5-min intervals during a sleep period, with an average sampling duration of 7 hr. For each of LH and T, we used the model-independent statistic approximate entropy (ApEn) to quantify the irregularity of the serum concentration time-series; to quantify joint LH-T secretory asynchrony, we employed the recently introduced cross-ApEn. Although mean (and SD) LH and T concentrations were indistinguishable in the two age groups (P > 0.25), for LH, aged subjects had greater ApEn values (1.525 +/- 0.221) than younger individuals (1.207 +/- 0.252), P < 0.003, indicating more irregular secretion in the older cohort. For T, aged subjects also had greater ApEn values (1.622 +/- 0.120) than younger counterparts (1.384 +/- 0.228), P < 0.004. In young, but not older men, ApE...Continue Reading

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Citations

Oct 30, 2003·Aging Clinical and Experimental Research·Gaetano Frajese, Flavio Pozzi
Jun 1, 2010·European Journal of Applied Physiology·C Martyn BeavenWill G Hopkins
Dec 4, 2008·Pituitary·Ferdinand RoelfsemaJohannes A Romijn
Apr 1, 2000·Journal of the American Aging Association·W A Banks, J E Morley
Jun 15, 2013·Human Movement Science·Eric G James, Murat Karabulut
May 27, 2005·Journal of Theoretical Biology·Daniel M KeenanJohannes D Veldhuis
Jun 29, 2004·Psychoneuroendocrinology·Joel A PosenerAlan F Schatzberg
Dec 26, 2001·Archives of Medical Research·M BarontiniJ D Veldhuis
Jun 28, 2003·Neurobiology of Aging·Johannes D Veldhuis
Dec 13, 2000·Experimental Gerontology·J D Veldhuis
Dec 13, 2000·Experimental Gerontology·M HermannP Berger
Jun 19, 2001·Experimental Gerontology·M Hermann, P Berger
Nov 15, 2002·Nature·Timothy G Buchman
Feb 27, 2013·Nature Reviews. Endocrinology·Johannes D Veldhuis
Jan 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alvin M Matsumoto
Aug 28, 1998·Current Opinion in Obstetrics & Gynecology·S M Pincus, M J Minkin
Dec 24, 2005·Critical Care Medicine·Roberto HorneroBrahm Goldstein
Sep 9, 2011·American Journal of Physiology. Endocrinology and Metabolism·Xin WangJohannes D Veldhuis
Jul 20, 2012·American Journal of Physiology. Endocrinology and Metabolism·Johannes D VeldhuisDaniel M Keenan
Aug 5, 2010·American Journal of Physiology. Endocrinology and Metabolism·Johannes D VeldhuisSuanne M Weist
Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johannes D Veldhuis, Cyril Y Bowers
Sep 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johannes D VeldhuisJean R Wigham
Jun 26, 2004·Hormone Research·A J FogtelooA E Meinders
Apr 29, 1998·The Journal of Clinical Investigation·S M PincusA Rees Midgley
Oct 23, 2008·Endocrine Reviews·Johannes D VeldhuisSteven M Pincus
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes D Veldhuis, Ali Iranmanesh
Oct 21, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisThomas Mulligan
Dec 2, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisChristina Wang
Jan 7, 2005·The Journal of Clinical Endocrinology and Metabolism·Cacia Soares-WelchJohannes D Veldhuis
Jul 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Ali IranmaneshJohannes D Veldhuis
Mar 1, 2012·PloS One·Ferdinand RoelfsemaJohannes D Veldhuis
Dec 1, 2007·Clinical Interventions in Aging·Giovanni Vanni FrajeseGaetano Frajese
Feb 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·B H Singer, S Pincus
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Pincus, R E Kalman
Mar 4, 1998·Proceedings of the National Academy of Sciences of the United States of America·J LicinioP W Gold
Sep 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Steve Pincus, Rudolf E Kalman
Apr 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Daniel M KeenanJohannes D Veldhuis
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bulent O YildizJulio Licinio
May 15, 2009·Journal of Medical Engineering & Technology·S A Ahmad, P H Chappell

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