Oleanolic acid protects against myocardial ischemia-reperfusion injury by enhancing mitochondrial antioxidant mechanism mediated by glutathione and alpha-tocopherol in rats

Planta medica
Ying Du, Kam Ming Ko

Abstract

The effect of oleanolic acid (OA) pretreatment on myocardial ischemia-reperfusion (I-R) injury was investigated using an ex vivo rat heart model. Pretreatment with OA at daily doses (0.6 and 1.2 mmol/kg) for 3 days significantly protected against I-R injury in isolated rat hearts, as evidenced by the decrease in the extent of lactate dehydrogenase (LDH) leakage and improvement in contractile force recovery. The cardioprotection was associated with a slight increase in mitochondrial reduced glutathione (GSH) level and a significant increase in mitochondrial alpha-tocopherol (alpha-TOC) level, when compared with the unpretreated I-R group. To further investigate the mechanism of myocardial protection, pretreatment with a single dose of OA (1.2 mmol/kg) produced a time-dependent protection against myocardial I-R injury as assessed by LDH leakage, with the maximum extent of protection occurring at 48 hour post-dosing. The maximum cardioprotection was associated with parallel increases in mitochondrial GSH and alpha-TOC levels in ischemic-reperfused hearts, with the stimulation of the alpha-TOC level being optimal. Furthermore, buthionine sulfoximine/phorone (BSO/PHO) treatment, while abolishing the enhancing effect of OA on mitocho...Continue Reading

Citations

Jun 27, 2009·Archives of Pharmacal Research·Soon Ock ChoYeon Hee Seong
Jul 24, 2012·Journal of Agricultural and Food Chemistry·Mei-Chin YinChia-Yu Lin
Mar 26, 2016·Journal of Agricultural and Food Chemistry·Filomena S G SilvaMaria Fatima Duarte
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Mar 27, 2018·Journal of the Science of Food and Agriculture·Joaquín VelascoMaría Victoria Ruiz-Méndez
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