Oleic acid-associated bronchiolitis obliterans-organizing pneumonia in beagle dogs

Veterinary Pathology
X LiR Adler

Abstract

Accidental intra-airway exposure of dogs with pure oleic acid produced bronchiolitis obliterans and bronchopneumonia. Pulmonary changes included multifocal to coalescing necrosis of bronchioles and adjacent alveoli, hemorrhage, inflammation, and exudation of fibrin. Hyperplasia of bronchiolar and alveolar epithelial cells and proliferation of loose fibrovascular connective tissue formed polyps or plugs of variable size and shape. Polyps in the airways primarily consisted of fibroblasts with loose or myxoid stroma and were variably covered with attenuated epithelial cells. Some polyps had prominent vasculature, mixed inflammatory cell infiltration, and/or necrosis. Polyps or plugs variably effaced bronchioles and adjacent alveoli. The changes closely resembled human bronchiolitis obliterans-organizing pneumonia (BOOP). Controlled intra-airway delivery of oleic acid in dogs may be a potential animal model of obstructive pulmonary diseases such as BOOP or bronchiolitis obliterans.

References

Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B ZwisslerK Messmer
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·I A Spahr-SchopferM Dolovich
Mar 1, 1997·The Journal of Nutrition·J M BourreG A Durand
Aug 29, 1998·Intensive Care Medicine·H MoriuchiT Yuizono
Oct 20, 1998·Journal of Toxicology. Clinical Toxicology·T OkumuraA Kohama
Feb 15, 2001·Archives of Internal Medicine·G R Epler
May 8, 2003·Intensive Care Medicine·Ives HubloueMarc Leeman

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Citations

Oct 27, 2010·Journal of Biomedicine & Biotechnology·Ching-Chang ChengYung-Tsung Chiu
Jun 13, 2008·International Archives of Occupational and Environmental Health·David Galbraith, David Weill
Nov 22, 2011·Transplantation Proceedings·S De VleeschauwerG Verleden
Mar 18, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Abhishek MathurHenry A Pitt
Aug 19, 2007·The Veterinary Clinics of North America. Small Animal Practice·Carol R Reinero, Leah A Cohn
Jan 13, 2009·British Journal of Pharmacology·Ju-Ping LaiDaren L Knoell
Jan 18, 2019·Journal of the American Animal Hospital Association·Stacey Lynn WylieKurt J Williams
Jul 21, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Miguel F CarrilloFrancisco R Carvallo

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