Oleic acid lung injury: a morphometric analysis using computed tomography

Acta Anaesthesiologica Scandinavica
C RylanderG Hedenstierna

Abstract

The oleic acid-induced lung injury (OAI) model is considered to represent the early phase of acute respiratory distress syndrome (ARDS). Its inherent properties are important for the design and the interpretation of interventional studies. The aim of this study was to describe the evolution of morphometric lung changes during OAI using computed tomography (CT) analysis. Furthermore, the effect of a temporary change in positive end-expiratory pressure (PEEP) was evaluated. Fifteen anaesthetized pigs were ventilated in volume-controlled mode with a baseline PEEP of 5 cm H(2)O. Helical CT scans were taken at baseline and 1 h after oleic acid injection. The PEEP was then either increased to 10 cm H(2)O (n = 5), decreased to 0 cm H(2)O (n = 5) or kept constant (n = 5) for 30 min. For the next 30 min, the baseline PEEP level was applied in all animals before the final CT scans 2 h after the induction of OAI. Dimensional and volumetric changes were determined from radiographical attenuation values. There was a major decrease in gas volume and an increase in tissue volume within the first hour. A net increase in total lung volume, with a larger transverse area but no displacement of the diaphragm, was manifest after 2 h. A minor increa...Continue Reading

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Citations

Sep 11, 2007·Critical Care Medicine·Luna GarganiEugenio Picano
May 20, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Angela HansonGöran Hedenstierna
Jan 10, 2009·Annals of Plastic Surgery·Silas W SmithLewis S Nelson
Oct 14, 2006·American Journal of Respiratory and Critical Care Medicine·Pier Paolo TerragniV Marco Ranieri
Mar 7, 2009·Critical Care : the Official Journal of the Critical Care Forum·Anneli FagerbergAnders Aneman
Oct 30, 2010·Ultrasound in Medicine & Biology·Zoltán JambrikEugenio Picano
Jan 30, 2009·Acta Anaesthesiologica Scandinavica·A FagerbergA Aneman
Aug 30, 2005·Respiratory Physiology & Neurobiology·Walid HabreFerenc Peták
Aug 6, 2021·Critical Care : the Official Journal of the Critical Care Forum·Mariangela PellegriniGaetano Perchiazzi

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