Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery

Medicines
Pawan KumarHimanshu Kathuria

Abstract

Current topical minoxidil (MXD) formulations involve an unpleasant organic solvent which causes patient incompliance in addition to side effects in some cases. Therefore, the objective of this work was to develop an MXD formulation providing enhanced follicular delivery and reduced side effects. Oleic acid, being a safer material, was utilized to prepare the nanovesicles, which were characterized for size, entrapment efficiency, polydispersity index (PDI), zeta potential, and morphology. The nanovesicles were incorporated into the emugel Sepineo® P 600 (2% w/v) to provide better longer contact time with the scalp and improve physical stability. The formulation was evaluated for in vitro drug release, ex vivo drug permeation, and drug deposition studies. Follicular deposition of the vesicles was also evaluated using a differential tape stripping technique and elucidated using confocal microscopy. The optimum oleic acid vesicles measured particle size was 317 ± 4 nm, with high entrapment efficiency (69.08 ± 3.07%), narrow PDI (0.203 ± 0.01), and a negative zeta potential of -13.97 ± 0.451. The in vitro drug release showed the sustained release of MXD from vesicular gel. The skin permeation and deposition studies revealed superior...Continue Reading

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Citations

Feb 1, 2020·Expert Opinion on Drug Delivery·Waleed AlsalhiAntonella Tosti
Jan 15, 2020·Current Pharmaceutical Design·Maryam ShabbirKashif Barkat
Jul 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shefrin Salim, Kaladhar Kamalasanan
May 1, 2021·Pharmaceutics·Maria Chiara CristianoDonatella Paolino
Aug 22, 2021·Colloids and Surfaces. B, Biointerfaces·Priya MishraRahul Shukla

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Methods Mentioned

BETA
Dynamic light scattering
X-ray
biopsy

Software Mentioned

Zetasizer

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