PMID: 8608161Mar 29, 1996Paper

Oleic acid-rich fats increase the capacity of postprandial serum to promote cholesterol efflux from Fu5AH cells

Biochimica Et Biophysica Acta
S W SakrA Girard-Globa

Abstract

Cell cholesterol efflux to serum is stimulated after an oral fat load. The impact of meal fatty acid composition was explored by measure of serum promoted cholesterol efflux from Fu5AH cells after ingestion of 4 different fats: sunflower (Sf), oleic-sunflower (Ol), a mixed oil (Mx), and beef tallow (Bt). High density lipoprotein (HDL)2 and HDL3 were isolated and analyzed. Cholesterol efflux increased regularly after Ol (P<0.05 at 4 h and P<0.02 at 8 h), and 8 h after Mx (P<0.02) or Bt (P<0.05), but not after Sf. Percent HDL3 phospholipids increased after Ol (P<0.05 at 6 h and P<0.01 at 8 H) and 8 h after Mx (P<0.01). After Ol, variations in efflux and percent phospholipids in HDL3 (but not HDL2) were positively correlated (r=0.929; P=0.007 at 6 h). Using HDL3, efflux increased 6 h after Ol (P<0.05) but not after Sf, and efflux was correlated with HDL3 phospholipid concentration in medium (r=0.913; P=0.011). Thus postprandial increase in cholesterol efflux in influenced by ingested fats in relation to increased phospholipid availability on HDL3. The protective effect of monounsaturated fatty acids against atherogenesis might be partly mediated by an enhanced ability of postprandial serum to accept cell cholesterol.

References

Aug 1, 1992·The Journal of Nutrition·T J Kalogeris, J A Story
Apr 1, 1991·European Journal of Clinical Investigation·P N DemackerA F Stalenhoef
Oct 1, 1991·Biochimica Et Biophysica Acta·W J JohnsonM C Phillips
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
May 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M Van Heek, D B Zilversmit
Nov 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D Reichl, N E Miller
Dec 1, 1986·American Journal of Epidemiology·A KeysM H Keys
Mar 1, 1985·The Journal of Clinical Investigation·G R Castro, C J Fielding
Jan 1, 1985·Advances in Lipid Research·P Tso
Mar 28, 1985·The New England Journal of Medicine·A C ArntzeniusE A van der Velde
Dec 1, 1984·The Journal of Clinical Investigation·J R PatschG Bengtsson-Olivecrona
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y HuangG Assmann

❮ Previous
Next ❯

Citations

May 5, 2012·Progress in Lipid Research·Jean-Luc CacasSébastien Mongrand
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Aafje SierksmaHenk F J Hendriks
Aug 8, 2013·Food & Function·Catherine J Andersen, Maria Luz Fernandez
Feb 28, 2002·The American Journal of Clinical Nutrition·Maria Teresa MontoyaGraciela Rosa Castro
Nov 10, 2007·The American Journal of Clinical Nutrition·Vivian BuonacorsoAna Maria P Lottenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.