Oleic acid synthesized in the periventricular zone promotes axonogenesis in the striatum during brain development

Journal of Neurochemistry
Erica Polo-HernándezJosé M Medina

Abstract

Our previous works showed that oleic acid synthesized in vitro by astrocytes in response to albumin behaves as a neurotrophic factor in neurons, up-regulating several proteins, such as the axonal growth marker growth-associated protein 43(GAP-43). Although the molecular mechanism of this process is fairly known, there is no evidence pinpointing the region/s in which oleic acid is synthesized. In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. In addition, the spatio-temporal presence of albumin - the signal that promotes oleic acid synthesis - and that of GAP-43 are correlated with that of SCD-1. Using organotypic slice cultures, we found that albumin up-regulates SCD-1 and stimulates the growth of GAP-43-positive axons in the striatum. The effect of albumin on GAP-43 was reduced when SCD-1 was silenced by siRNA. In conclusion, our results suggest that albumin up-regulates axonogenesis in the striatum by increasing the amount of the neurotrophic factor oleic acid synthesized by SCD-1 in the periventricular zone of the new...Continue Reading

References

Jan 1, 1991·Neuroscience·J W DaniL I Benowitz
Jan 1, 1989·Annual Review of Neuroscience·J H Skene
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P N Hoffman, D W Cleveland
Mar 1, 1980·The Journal of Physiology·K M DziegielewskaN R Saunders
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
Nov 10, 2001·Journal of Neurochemistry·A TaberneroJ M Medina
Nov 26, 2002·Journal of Physiology, Paris·José M Medina, Arantxa Tabernero
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Apr 27, 2004·Molecular Biology of the Cell·Deepak K SharmaRichard E Pagano
Jun 1, 2004·Experimental Biology and Medicine·Gerald J Mizejewski
Jan 25, 2007·Neurosurgery Clinics of North America·Daniel A LimArturo Alvarez-Buylla

❮ Previous
Next ❯

Citations

May 29, 2013·Lipids in Health and Disease·Jade GuestRoss Grant
Sep 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Michael P SchwartzJames A Thomson
Jun 13, 2012·Journal of Chemical Neuroanatomy·Priscila Pereira PassosBelmira Lara da Silveira Andrade-da-Costa
May 25, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Maria C MedeirosTania M Stamford
May 13, 2020·The American Journal of Clinical Nutrition·Annelise A MadisonJanice K Kiecolt-Glaser
Sep 12, 2018·Nutrients·Lorena Gimenez da Silva-SantiRoberto Barbosa Bazotte
Jul 26, 2019·Scientific Reports·Jungbin SongHocheol Kim
Jan 29, 2020·Advanced Drug Delivery Reviews·Jeroen F J BogieJerome J A Hendriks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.